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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Ετικέτες
Τρίτη 25 Σεπτεμβρίου 2018
Scholar : New articles have been published for Journal of Natural History, Volume 52, Issue 33-34
Effect of vitamin D supplementation along with weight loss diet on meta‐inflammation and fat mass in obese subjects with vitamin D deficiency: a double‐blind placebo‐controlled randomized clinical trial
Clinical Endocrinology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2xBIB8u
Correction to: Glucose in Conjunction with Multiple Laser Pulses on Laser Treatment of Port-wine Stain: An in vivo Study
In the originally published article, the title was incorrectly copied from another article. The correct title is "Glucose in Conjunction with Multiple Laser Pulses on Laser Treatment of Port-wine Stain: An in vivo Study", which is also shown above.
https://ift.tt/2xBIf1E
Successful treatment of dermatomyositis with low‐dose naltrexone
Dermatologic Therapy, EarlyView.
https://ift.tt/2PXQf3C
Anti‐desmoglein‐1 levels as predictor of prednisolone tapering in pemphigus vulgaris patients treated with rituximab
Dermatologic Therapy, EarlyView.
https://ift.tt/2O6NNuy
Circumcision is still the gold standard in management of plasma cell balanitis
Dermatologic Therapy, EarlyView.
https://ift.tt/2Q2r7c5
Is skin microneedling a good alternative method of various skin defects removal
Dermatologic Therapy, EarlyView.
https://ift.tt/2Oaxugc
The therapeutic effect of tanshinone IIA on Propionibacterium acnes‐induced inflammation in vitro
Dermatologic Therapy, EarlyView.
https://ift.tt/2Q2l4V2
A case series of dupilumab‐treated allergic contact dermatitis patients
Dermatologic Therapy, EarlyView.
https://ift.tt/2ObsKH2
Short‐ and long‐term effects of two emollients on itching and skin restoration in xerotic eczema
Dermatologic Therapy, EarlyView.
https://ift.tt/2Q2vYKo
Dabrafenib plus trametinib in BRAF K601E‐mutant melanoma
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2zs2AYu
Does Helicobacter pylori infection increase the risk of Barrett's esophagus and esophageal adenocarcinoma?
Helicobacter, EarlyView.
https://ift.tt/2NFW1KP
Multinucleate Cell Angiohistiocytoma: Case Report and Literature Review
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2Oea21w
Post‐Radiation Vascular Lesions of the Breast
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2Q8a9JF
Co‐existence of Langerhans cell histiocytosis and reticulohistiocytosis with initial presentation of skull lesions: A case report
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2xNTnbb
One‐year follow‐up results of hair removal using an 810 nm diode laser
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2zsitOV
Cosmeceutical potential of geranium and calendula essential oil: Determination of antioxidant activity and in vitro sun protection factor
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2OPdaOz
Increased risk of severe course of pemphigus in patients with pemphigus‐associated alopecia: a prospective observational study
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2Q5AF6q
Silver nanoparticles induce Egr‐1‐dependent psoriasin expression via the ERK and p38 pathways
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2ObgGWg
Δευτέρα 24 Σεπτεμβρίου 2018
Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis
Abstract
Lymphangiogenesis plays a crucial role in promoting cancer metastasis to sentinel lymph nodes (LNs) and beyond. Increasing data have shown that simvastatin, a cholesterol-lowering medication for the prevention of cardiovascular diseases, is involved in tumor growth and dissemination, and endothelial functions. This study aimed to investigate the potential effect of simvastatin on lymphatic formation and LN metastasis. Tumor models were established by subcutaneous injection of B16-F10 melanoma cells into mouse hind footpads. Simvastatin was administered (0.2 µg/g, intraperitoneal injection, IP) every other day for a total of eight times. Tissue samples were removed and examined by immunohistochemical staining and reverse transcription-polymerase chain reaction (RT-PCR) techniques. The lymphatics of LN, skin, liver, and lung exhibited morphological changes, and LN weight and metastatic area of the tumor group treated with simvastatin was lower than that of the untreated tumor group. Analysis of lymphatic size, area fraction, and lymphatic vessel density showed tissue specificity and variation to melanoma carcinogenesis in the simvastatin-treated group compared with the untreated group. In addition, LNs and cutaneous tissues showed altered expression of lymphangiogenic factors and inflammatory cytokines such as VEGF-A/-C/-D and TNF-α. These findings indicated that simvastatin may modify lymphangiogenesis and tumor progression in malignant melanoma.
https://ift.tt/2OdR8YC
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Publication date: September 2017 Source: Free Radical Biology and Medicine, Volume 110 Author(s): Lucía Fernández-del-Río, Anish Nag, Elen...
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Abstract Noise pollution is a major factor of environmental complaints in many cities, which has significant impacts on human health. As a...