Investigating mobility of crude oil adsorbates on mineral surfaces by NMR

Publication date: Available online 15 October 2018

Source: Magnetic Resonance Imaging

Author(s): Henrik N. Sørgård, Christian Totland, Willy Nerdal, John Georg Seland

Abstract

We have applied diffusion and relaxation Nuclear Magnetic Resonance experiments to investigate the translational and rotational mobility of adsorbents on quartz and calcite mineral surfaces. On both surfaces it was found that water is the dominant molecule. On the quartz surface the majority of water molecules have a relatively high degree of both rotational and translational mobility, while a minor fraction of water molecules, and all hydrocarbon molecules, have a significantly lower mobility. On the calcite surface the translational mobility is very low for all the adsorbed molecules, while there is a large diversity in rotational mobility, indicating that the hydrocarbon molecules are strongly attached to the surface, but that some part of each molecule still have a large degree of rotational mobility. Diffusion and relaxation experiments give a detailed description of both the molecular mobility of adsorbed species on these mineral surfaces, which leads to new insight with respect to aging processes on a molecular level.

https://ift.tt/2yGwuXo

Under-sampling and compressed sensing of 3D spatially-resolved displacement propagators in porous media using APGSTE-RARE MRI

Publication date: Available online 15 October 2018

Source: Magnetic Resonance Imaging

Author(s): Daan W. de Kort, Stefan A. Hertel, Matthias Appel, Hilko de Jong, Michael D. Mantle, Andrew J. Sederman, Lynn F. Gladden

Abstract

A method for under-sampling and compressed sensing of 3D spatially-resolved propagators is presented and demonstrated for flow in a packed bed and a heterogeneous carbonate rock. By sampling only 12.5% of q,k-space, the experimental acquisition time was reduced by almost an order of magnitude. In particular, for both systems studied, a 3D image was acquired at 1 mm isotropic spatial resolution such that 134,400 local propagators were obtained. Data were acquired in ~1 h and ~11 h for the packed bed and rock, respectively. It is shown that spatial resolution and under-sampling using this implementation retains the quantitative nature of the propagator measurement, and differences between implementation of this measurement in two and three dimensions are identified. The potential for 3D spatially-resolved propagators to provide new insights into transport processes in porous media by characterisation of the statistical moments of the propagators is discussed.

Graphical abstract

https://ift.tt/2yjUEI0

Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival

Abstract

Epidemiological studies show a reduced risk of breast cancer (BC) in women consuming high levels of long-chain (LC) omega-3 (ω-3) fatty acids (FAs) compared with women who consumed low levels. However, the regulatory and mechanistic roles of dietary ω-6 and LC-ω-3 FAs on tumor progression, metastasis and survival are poorly understood. Female BALB/c mice (10-week old) were pair-fed with a diet containing ω-3 or an isocaloric, isolipidic ω-6 diet for 16 weeks prior to the orthotopic implantation of 4T1 mammary tumor cells. Major outcomes studied included: mammary tumor growth, survival analysis, and metastases analyses in multiple organs including pulmonary, hepatic, bone, cardiac, renal, ovarian, and contralateral MG (CMG). The dietary regulation of the tumor microenvironment was evaluated in mice autopsied on day-35 post tumor injection. In mice fed the ω-3 containing diet, there was a significant delay in tumor initiation and prolonged survival relative to the ω-6 diet-fed group. The tumor size on day 35 post tumor injection in the ω-3 group was 50% smaller and the frequencies of pulmonary and bone metastases were significantly lower relative to the ω-6 group. Similarly, the incidence/frequencies and/or size of cardiac, renal, ovarian metastases were significantly lower in mice fed the ω-3 diet. The analyses of the tumor microenvironment showed that tumors in the ω-3 group had significantly lower numbers of proliferating tumor cells (Ki67⁺)/high power field (HPF), and higher numbers of apoptotic tumor cells (TUNEL⁺)/HPF, lower neo-vascularization (CD31⁺ vessels/HPF), infiltration by neutrophil elastase⁺ cells, and macrophages (F4/80⁺) relative to the tumors from the ω-6 group. Further, in tumors from the ω-3 diet-fed mice, T-cell infiltration was 102% higher resulting in a neutrophil to T-lymphocyte ratio (NLR) that was 76% lower (p < 0.05). Direct correlations were observed between NLR with tumor size and T-cell infiltration with the number of apoptotic tumor cells. qRT-PCR analysis revealed that tumor IL10 mRNA levels were significantly higher (six-fold) in the tumors from mice fed the ω-3 diet and inversely correlated with the tumor size. Our data suggest that dietary LC-ω-3FAs modulates the mammary tumor microenvironment slowing tumor growth, and reducing metastases to both common and less preferential organs resulting in prolonged survival. The surrogate analyses undertaken support a mechanism of action by dietary LC-ω-3FAs that includes, but is not limited to decreased infiltration by myeloid cells (neutrophils and macrophages), an increase in CD3⁺ lymphocyte infiltration and IL10 associated anti-inflammatory activity.

https://ift.tt/2P6Jtw0

Effect of a structured plaque control on MMP-1 and MMP-9 crevicular levels in patients with desquamative gingivitis associated with oral lichen planus

Abstract

Objectives

No data are available in the literature on the extent to which the immune host-response and bacterial-elicited inflammation separately contributes to the increase in gingival crevicular fluid (GCF) levels of inflammatory biomarkers in patients affected by desquamative gingivitis (DG) secondary to oral lichen planus (OLP). The aim of this study was to investigate the effect of a structured plaque control intervention on GCF levels of MMP-1 and MMP-9 in OLP patients with DG and to compare them with those of non-OLP patients.

Materials and methods

The study population consisted of 18 unrelated Caucasian patients with DG, while 18 periodontally healthy subjects were recruited for the control group. Periodontal parameters and GCF biomarker amounts were evaluated at baseline and 2 months after a structured plaque control intervention, comprising professional oral hygiene sessions, manual toothbrushing, and interdental cleaning advice, only for DG patients. Determination of MMP-1 and MMP-9 levels was carried out by means of an enzyme-linked immunosorbent assay.

Results

Plaque control program led to improvement in all examined clinical parameters and resulted in significant decrease in GCF total amount and concentration of MMP-1 and MMP-9 in comparison to baseline (p < 0.001). However, MMP-1 and MMP-9 levels in DG patients were still significantly higher than those in the healthy control group (p < 0.01).

Conclusions

These findings would seem to support an intrinsic upregulated expression of MMPs in DG patients that is exacerbated by bacterial plaque.

Clinical relevance

The present outcomes provide further scientific grounds for the importance of strict professional oral hygiene sessions in DG patients.

https://ift.tt/2QQitOr

Quantitative and qualitative assessment of sensory changes induced by local anesthetics block of two different trigeminal nerve branches

Abstract

Objectives

The aims were to use different techniques to assess the degree of sensory changes and magnitude of perceived size changes in the facial region induced by nerve blocks of two different trigeminal nerve branches in healthy participants.

Materials and methods

This placebo-controlled study included 30 healthy volunteers. The participants underwent quantitative and qualitative sensory testing (QST and QualST) thrice: before, 10 min, and 2 h after mental (n = 15) and infraorbital (n = 15) nerve blocks and during control (saline) sessions. Perceived numbness, temperature changes, and perceptual distortion were also measured at all time points during the nerve block and control sessions. Differences in outcome parameters between the sessions and time points were analyzed using analyses of variance and McNemar's tests.

Results

There was a significant degree of sensory loss to most QST and all QualST parameters, with significant numbness and increased perceived size at the injection site 10 min and 2 h after the nerve blocks compared with saline (P < 0.030) and the baseline (P < 0.042). Two hours after the nerve blocks, the sensitivity was significantly closer to baseline than after 10 min to most of the QST parameters (P < 0.011).

Conclusions

QST and QualST revealed that the nerve blocks in the orofacial region resulted in complete or partial blockade of afferent nerve fibers mediating thermal and mechanical function for more than 2 h with significant numbness and perceptual distortion.

Clinical relevance

Both QST and QualST can provide information on the degree of blockade of afferent nerve fibers after nerve blocks in the orofacial region.

https://ift.tt/2PCh7q6

Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition

Publication date: Available online 15 October 2018

Source: Journal of Autoimmunity

Author(s): Wenjun Liang, Junying Zhang, Margaux Saint-Martin, Fei Xu, Nelly Noraz, Jianmei Liu, Jérôme Honnorat, Heli Liu

Abstract

Accumulating evidence has showed that anti-CASPR2 autoantibodies occur in a long list of neurological immune disorders including limbic encephalitis (LE). Belonging to the well-known neurexin superfamily, CASPR2 has been suggested to be a central node in the molecular networks controlling neurodevelopment. Distinct from other subfamilies in the neurexin superfamily, the CASPR subfamily features a unique discoidin (Disc) domain. As revealed by our and others' recent studies, CASPR2 Disc domain bears a major epitope for autoantibodies. However, structural information on CASPR2 recognition by autoantibodies has been lacking. Here, we report the crystal structure of human CASPR2 Disc domain at a high resolution of 1.31 Å, which is the first atomic-resolution structure of the CASPR subfamily members. The Disc domain adopts a total β structure and folds into a distorted jellyroll-like barrel with a conserved disulfide-bond interlocking its N- and C-termini. Defined by four loops and located in one end of the barrel, the "loop-tip surface" is totally polar and easily available for protein docking. Based on structure-guided epitope prediction, we generated nine mutants and evaluated their binding to autoantibodies of cerebrospinal fluid from twelve patients with limbic encephalitis. The quadruple mutant G69N/A71S/S77N/D78R impaired CASPR2 binding to autoantibodies from eleven LE patients, which indicates that the loop L1 in the Disc domain bears hot spots for autoantibody interaction. Structural mapping of autoepitopes within human CASPR2 Disc domain sheds light on how autoantibodies could sequester CASPR2 ectodomain and antagonize its functionalities in the pathogenic processes.

https://ift.tt/2IXILvj

Thyroid dysfunction in children with leukemia over the first year after hematopoietic stem cell transplantation

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2ym795N

Leptin and adiposity as mediators on the association between early puberty and several biomarkers in European adolescents: the HELENA Study

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2yGMusy

High urate concentration is associated with elevated blood pressure in schoolchildren

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2ym6XDB

Increasing Frequency and Share of Dermatologic Procedures Billed by Non-Physician Clinicians from 2012-2016

Publication date: Available online 15 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Andrew T. Rogers, Ge Bai, Manisha J. Loss, Gerard F. Anderson

https://ift.tt/2pSV7fo

Scholar : ΜΕΝΙΕΡΕ - νέα αποτελέσματα

Clinical manifestations of hydropic ear disease (Menière's)

R Gürkov, C Jerin, W Flatz, R Maxwell - European Archives of Oto-Rhino-Laryngology, 2018

Page 1. Vol.:(0123456789) 1 3 European Archives of Oto-Rhino-
Laryngology https://ift.tt/2ykTTOJ OTOLOGY Clinical
manifestations of hydropic ear disease (Menière's) Robert Gürkov1 …

[PDF] Perfusion by delayed time to peak in vertebrobasilar dolichoectasia patients with vertigo

YF Peng, HL Zhang, DP Zhang, M Zhao, SL Zhang… - Annals of Clinical and …, 2018

… test. Those with definitive diagnosis of benign paroxysmal positional vertigo (BPPV),
Meniere's Disease, aural vertigo, recurrent ischemic strokes, atrial fibrillation, or
congenital heart disease history were ineligible for inclusion …

[PDF] Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity

S Garneau-Tsodikova, HX Ngo, SK Shrestha - US Patent App. 15/940,544, 2018

… biological pathways. Mol. Biol. Rep. 41, 4865-4879). Ebselen is currently in phase
2 clinical trials for the treatment of chemotherapy-induced hearing loss and Meniere's
disease (https://ift.tt/KkipBP). Furthermore, ebselen …

Technological Evolution of Thin-film Solar Cells through Main Path Analysis

V Kumar, HC Chen, CY Lin, KK Lai, YH Chang - … on E-Society, E-Education and E …, 2018

… Patent portfolios and knowledge flow(s) of photovoltaic companies.
Technology Analysis & Strategic Management, 1-18. [4] de la Tour, A.,
Glachant, M., & Meniere, Y. (2011). Innovation and international technology …

[PDF] Phosphorylcholine conjugates and uses thereof

Y Shoenfeld, M Blank - US Patent App. 15/991,335, 2018

… diabetes (Type 1 diabetes), juvenile myositis, Kawasaki syndrome,
Lambert-Eaton syndrome, leukocytoclastic vasculitis, lichen planus, lichen
sclerosus, ligneous conjunctivitis, linear IgA disease (LAD), Lupus (SLE) …

[PDF] Composite granulated product including sugar or sugar alcohol, swelling binder, disintegrating agent and highly absorbent excipient, and method for manufacturing …

S Uramatsu, T Uemura, M MORIZANE, T Shimamoto - US Patent App. 15/765,808, 2018

US20180280304A1 - Composite granulated product including sugar or sugar alcohol,
swelling binder, disintegrating agent and highly absorbent excipient, and method for
manufacturing composite granulated product - Google Patents …

[PDF] A retrospective analysis of haemotologic parameters in patients with bilateral tinnitus

U Düzenli, N Bozan, M Aslan, H Özkan, M Turan… - Age

… However, there are not any certain pathophysiological explanations about tinnitus
(15- 17). This clinical problem can occur at older ages and decrease hearing caused
by any ear diseases like otosclerosis, Meniere etc. noise …

[PDF] Schwindel: Wir wissen zu wenig und schwindeln zu viel darüber

S Hegemann

… DOI: https://ift.tt/2ykUxM9 6. Adrion C, Fischer CS, Wagner
J, Gürkov R, Mansmann U, Strupp M: Ef- ficacy and safety of betahistine
treatment in patients with Meniere's disease: primary results of a long term …

[PDF] Biofunctionalized nanoparticles and uses thereof in adoptive cell therapy

A Sicard, O Thaunat - US Patent App. 15/763,566, 2018

US20180280536A1 - Biofunctionalized nanoparticles and uses thereof in adoptive
cell therapy - Google Patents. Biofunctionalized nanoparticles and uses thereof in
adoptive cell therapy. Download PDF Info. Publication number …

[PDF] Use of flaxseed and flaxseed derivatives for treatment of neurological disorders and viral diseases

M Christofidou-Solomidou, K JORDAN-SCIUTTO - US Patent App. 15/995,128, 2018

US20180280462A1 - Use of flaxseed and flaxseed derivatives for treatment of neurological
disorders and viral diseases - Google Patents. Use of flaxseed and flaxseed derivatives
for treatment of neurological disorders and viral diseases. Download PDF Info …

 

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Scholar : ΣΤΟΜΑΤΙΤΙΣ - νέα αποτελέσματ

Evaluation of the efficacy of the subcutaneous low recombinant feline interferon-omega administration protocol for feline chronic gingivitis-stomatitis in feline calicivirus …

H Matsumoto, T Teshima, Y Iizuka, A Sakusabe… - Research in Veterinary …, 2018

We investigated the clinical effectiveness of subcutaneous (SC) administration of
recombinant feline interferon-omega (rFeIFN-ω) at a dose of 1 M unit (MU)/kg body
weight (bw) for the treatment of feline chronic gingivitis-stomatitis (FCGS) in cats …

[HTML] Association Between Anxiety, Depression, and Salivary Cortisol Levels in Patients with Recurrent Aphthous Stomatitis

C Polat, S Düzer, H Ayyıldız, S Seç, N Aksoy… - Turkish Archives of …, 2018

Objective Recurrent aphthous stomatitis (RAS) is the most common ulcerative
disease of the oral mucosa that commonly affects the general population. The
objective of this study was to conduct a research in assesing the relationship …

Aphthous Stomatitis and Laryngitis, Another Form of Presentation of an IgG4-Related Disease?

S Suárez-Díaz, F Núñez-Batalla, MS Fernández-García… - Reumatologia clinica, 2018

IgG4-related disease is characterized by a lymphoplasmacytic infiltrate rich in IgG4-
positive plasma cells, storiform fibrosis and obliterative phlebitis. It can present as
parotid gland enlargement, tubulointerstitial nephritis, retroperitoneal fibrosis or …

[PDF] Coexistence of PFAPA syndrome with separation anxiety

YE Donmez, O Ozcan, Y Tabel - 2018

… Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome
(PFAPA syndrome) is an autoinflammatory disease characterized by existence
of fever attacks with at least one of the three major symptoms as aphthous …

[PDF] The assessment of contributing factors to oral ulcer presence in Behçet's disease: Dietary and non-dietary factors

M İris, E Özçıkmak, A Aksoy, F Alibaz-Öner, N İnanç… - 2018

… Several studies have noted the protective effect of smoking on oral ulcer presence in BD
and re- current aphthous stomatitis (32, 33) … Page 4. Similarly, stress is reported to be
associated with oral ulcer activity in patients with recurrent aph- thous stomatitis (30) …

[HTML] Influence of the use of complete denture adhesives on microbial adhesion and biofilm formation by single-and mixed-species

NM de Oliveira Junior, DOM Marin, ARP Leite, AC Pero… - PloS one, 2018

… complete dentures [1,2,6,7]. Denture stomatitis, a fungal infection that affects many
complete denture wearers, presents multifactorial etiology and has poor oral hygiene
as a major predisposing factor [10–12]. Lack of proper care is …

Collective Infection of Cells by Viral Aggregates Promotes Early Viral Proliferation and Reveals a Cellular-Level Allee Effect

I Andreu-Moreno, R Sanjuán - Current Biology, 2018

… Using vesicular stomatitis virus, here, we compare the fitness of free versus
saliva-aggregated viral particles … collective infectious unit. virus aggregation.
dispersal. virus transmission. Allee effect. infectivity. innate immunity. genetic …

Nanotechnology Toward Treating Cancer: A Comprehensive Review

G Pillai - Applications of Targeted Nano Drugs and Delivery …, 2019

… Lipodox has a circulation half-life of 55 h. However, due to the long circulation time of
the PEGylated drug, stomatitis (inflammation of mucus lining) became the new dose-limiting
toxicity … 225-fold increase in AUC. Dose-limiting toxicity is stomatitis and skin toxicity …

Progressing from transient to stable packaging cell lines for continuous production of lentiviral and gammaretroviral vectors

J Park, S Inwood, S Kruthiventi, J Jenkins, J Shiloach… - Current Opinion in Chemical …, 2018

… Selection of viral envelope. The most widely used lentiviral vector is derived
from human immunodeficiency virus type 1 (HIV-1) and often pseudotyped
with the vesicular stomatitis virus-glycoprotein (VSV-G) envelope due to …

[HTML] Robust Enhancement of Lentivirus Production by Promoter Activation

N Suzuki, T Yoshida, H Takeuchi, R Sakuma… - Scientific Reports, 2018

… The safety and convenience of lentiviral vectors have been improved over time by various
different procedures 1 . Vesicular stomatitis virus glycoprotein (VSV-G)-pseudotyped
lentiviral vectors are commonly produced in HEK293T cells under the control of the human …

 

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Scholar : intitle:laryngeal - new results

Airway Management and Clinical Outcomes in External Laryngeal Trauma: A Case Series.

AR DePorre, SA Schechtman, ND Hogikyan… - Anesthesia and analgesia, 2018

External laryngeal trauma is a rare but potentially fatal event that presents several
management challenges. This retrospective observational case series conducted at
a level-1 trauma center over a 12-year period consists of 62 cases of acute external …

Long noncoding RNA PVT1 promotes laryngeal squamous cell carcinoma development by acting as a molecular sponge to regulate miR‐519d‐3p

X Zheng, K Zhao, T Liu, L Liu, C Zhou, M Xu - Journal of cellular biochemistry, 2018

Objective This study was designed to investigate the effects and mechanism of long
noncoding RNA (lncRNA) PVT1 on cell migration, proliferation, and apoptosis of
laryngeal squamous cell carcinoma (LSCC). Methods We screened lncRNAs …

A Novel Laryngeal Palpatory Scale (LPS) in Patients with Muscle Tension Dysphonia

N Jafari, A Salehi, I Meerschman, F Izadi, A Ebadi… - Journal of Voice, 2018

Objectives Laryngeal palpation is a routine clinical method for evaluation of patients
with muscle tension dysphonia (MTD). The aim of this study was to develop a new
comprehensive valid and reliable "laryngeal palpatory scale"(LPS), based on …

Recurrent laryngeal nerve reinnervation: is this the standard of care for pediatric unilateral vocal cord paralysis?

MC Espinosa, J Ongkasuwan - Current opinion in otolaryngology & head and neck …, 2018

PURPOSE OF REVIEW: Ansa to recurrent laryngeal nerve reinnervation, otherwise
known as a nonselective laryngeal reinnervation (NSLR), is growing in popularity for
the management of pediatric unilateral neuronal vocal fold movement impairment …

The efficacy of ansa cervicalis anterior root for unilateral recurrent laryngeal nerve injury

YN Gao, SC Chen, DH Chen, M Li, W Wang, F Liu… - Zhonghua er bi yan hou tou …, 2018

Objective: To discuss the long-term efficacy of laryngeal reinnervation using the
anterior root of the ansa cervicalis in the treatment of unilateral vocal fold paralysis
(UVFP) caused by thyroid surgery. Method: From January 2010 to January 2016, a …

Dysphagia After Laryngeal Surgery

N Subramaniam, AV Nikitha, K Thankappan - Dysphagia Management in Head and …, 2018

Normal laryngeal function is crucial for the pharyngeal stage of deglutition. It is a
rapid, well-coordinated action, comprising the passage of food from the pharynx into
the upper esophageal sphincter (UES) and protection of the airway from aspiration …

Anticancer Activity of Mukonal Against Human Laryngeal Cancer Cells Involves Apoptosis, Cell Cycle Arrest, and Inhibition of PI3K/AKT and MEK/ERK Signalling …

L Li, L Huizhi, W Binu, D Xinxin, W Longjun, Y Liping… - Medical Science Monitor, 2018

BACKGROUND: Laryngeal cancer is one of the major malignancies of the neck and
head and is responsible for considerable mortality across the globe. The treatments
for laryngeal cancer mainly involve surgical interventions followed by chemotherapy …

Risk analysis for tracheostomy dependency in curatively treated laryngeal cancer with organ preservation

L Anschuetz, M Visini, M Shelan, O Elicin, R Giger - Head & neck, 2018

Background A tracheostomy has an enormous negative impact on the patient's
quality of life. The purpose of this study is to describe risk factors for permanent
tracheostomies in patients undergoing curative organ‐preserving treatment of …

Can laryngeal mask airway be used for surfactant administration in neonates?

AJ Groberg, JM Dintaman - Journal of Perinatology, 2018

Thank you for visiting nature.com. You are using a browser version with limited support
for CSS. To obtain the best experience, we recommend you use a more up to date browser
(or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued …

Laryngeal clefts: a review of current literature

ZB Wu, L Li - Zhonghua er bi yan hou tou jing wai ke za zhi …, 2018

Laryngeal clefts as exceptionally rare congenital anomalies have been reported
more and more recently. The clinical symptoms and presentations base on degree of
clefts and variety of comorbidities. Mild types of clefts may have minimal clinical …

Laryngeal physiology and terminology in CCM singing. A thesis investigating research on the underlying laryngeal physiology of CCM singing techniques, and …

I Vestfall - 2018

English: As a singing teacher, one may find that thorough and consistent descriptions
of the laryngeal physiology underlying various CCM singing techniques are hard to
come by. Books, blogs and magazines concerned with such issues seldom include …

Is C‐11 Methionine PET an alternative to 18‐F FDG PET for identifying recurrent laryngeal cancer after radiotherapy?

J Wedman, J Pruim, L van der Putten, OS Hoekstra… - Clinical Otolaryngology

Abstract 18F FDG PET is superior to other imaging techniques in revealing residual
laryngeal cancer after radiotherapy. Unfortunately, its specificity is low, due to FDG
uptake in inflammation and in anaerobic conditions. PET imaging with the amino …

 

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