Injectable soft tissue fillers were the 2nd most common minimally invasive cosmetic procedure with approximately 2.7 million performed in the United States in 2017.1 This minimally invasive procedure is performed by a myriad of practitioners with a widely divergent medical training background ranging from plastic surgeons, otolaryngologists, ophthalmologists, obstetricians, internists, dentists and nurses. The complications related to soft tissue fillers are well described in the literature.2,3,4,5 Given the frequency with which this procedure is performed and the varying medical training of the performing practitioners, efforts to improve the safety of this procedure should be encouraged and embraced.
https://ift.tt/2FGATAq
Σάββατο 24 Νοεμβρίου 2018
Title: Commentary – Novel technique of filler injection in the temple area using the vein detection device, Vein Probe࣪
Disseminated Trichosporonosis with Atypical Histology Findings in a Patient with Acute Lymphocytic Leukemia
We report a case of disseminated Trichosporon asahii in a patient on systemic anti‐fungal therapy who presented with multiple cutaneous nodules suggestive of fungal infection. Histologic features resembled neutrophilic eccrine hidradenitis but staining with periodic acid‐Schiff and Gomori methenamine silver confirmed the clinical diagnosis. This case highlights the importance of maintaining suspicion for trichosporonosis and contextualizing histologic findings within the underlying clinical picture.
This article is protected by copyright. All rights reserved.
https://ift.tt/2DLUeOf
What's new in the treatment of atopic dermatitis?
Atopic dermatitis (AD) is a pruritic, chronic and inflammatory skin disease, with an usual onset in the pediatric age. Several drugs are used in the treatment of this skin disease. Drugs as steroid, calcineurin inhibitors, and moisturizing creams are widely used in the treatment of this disease but often patients are not satisfied with the obtained results. New drugs like dupilumab or crisaborole seems to be a promising option for moderate and severe forms of AD. This paper analyzes the newest therapy available today for the treatment of AD.
This article is protected by copyright. All rights reserved.
https://ift.tt/2r3486n
Review of Future Insights of Dragon's Blood in Dermatology
Objective
To assess the possible clinical implication of Dragon's Blood in dermatology.
Design
A pubmed search was conducted using the keyword "Dragon's Blood", "Croton lechleri", and more.
Results
Dragon's Blood from Croton lechleri is an Amazonian medicinal plant with a characteristic red sap. Its array of phytochemical action in preclinical studies include anti‐inflammatory, anti‐oxidant, antimicrobial, antifungal, and antineoplastic properties. Clinical studies reflect wound healing and antiviral properties.
Conclusion
Although its popularity is rising in western medicine, C. lechleri offers limited use in dermatology and further investigation is necessary to gain further insight into its potential clinical implication.
This article is protected by copyright. All rights reserved.
https://ift.tt/2FCPHzS
Salutogenesis and beyond
In this hypothesis paper on paradoxes in preventive medicine, which also deals with the indocility of biological functions, the following issues will be addressed. First, a definition of salutogenesis will be given, providing the origin of this notion of health preservation and disease prevention. Then four paradoxes of the biology of health will be discussed. The first deals with the biomarkers of aging. The second addresses the good and bad of the much praised anti‐oxidants. The third details how the mTOR (mammalian transporter of rapamycin) pathway plays a discreet but fundamental role. The fourth explores the yin and yang effects of the secretory profile of senescent cells. In conclusion, the need for a new paradigm in preventive medicine will be proposed.
This article is protected by copyright. All rights reserved.
https://ift.tt/2FEPTin
Frontal pattern hair loss among Chinese women is frequently associated with ponytail hairstyle
Female alopecia patients in China often present with a frontal pattern hair loss. This feature is seen less frequently in western women. Women in China frequently style their hair in a ponytail. Thus, we hypothesized that the high prevalence of frontal pattern hair loss in Chinese women is due to traction alopecia. To better understand this, we studied forty‐three women presenting frontal alopecia at a hospital hair clinic. Among the women presenting frontal alopecia, 79% reported styling their hair in a ponytail four or more days per week for an average period of 10 years. To our knowledge, this is the first study to elucidate the cause of frequent frontal alopecia in Chinese women. While cultural style changes are difficult to change, we believe that awareness of the medical implications of frequent ponytail styling will reduce the rate of frontal alopecia among Chinese women.
This article is protected by copyright. All rights reserved.
https://ift.tt/2r4OAz2
Response of localized, resistant, tingling vitiligo to pregabalin: A case report
Abstract
Vitiligo is a common depigmenting disease with complex pathogenesis. One of the proposed pathogenesis is the neural hypothesis, which suggests an altered reaction to neuropeptides, catecholamines, and their metabolites affecting melanocytes. Here, we report a case of 26‐year‐old female patient, whose vitiligo patches were associated with unusual crawling and tingling sensation and responded to a clinical trial of pregabalin.
https://ift.tt/2r1uANw
Overview of high‐risk Food and Drug Administration recalls for cosmetics and personal care products from 2002 to 2016
Summary
Background
There have been several recent controversies surrounding cosmetic products that have impacted health. Dermatologists are often the first to encounter these issues, and recalls are one metric of a safety profile of cosmetics and their impact on health.
Objective
To analyze all recalls of cosmetic and personal care products from 2002 to 2016.
Methods
This observational study describes all FDA cosmetic and personal care product recalls, acquired via a Freedom of Information Act request, from 2002 to 2016. The total number of Class I, Class II, and Class III recalls, number and origin of manufacturers, number of products affected, and main reason for recall were collected.
Results
A total of 14 Class I, 266 Class II, and 33 Class III recalls were recorded. Baby products comprised the largest product category accounting for 24% of all recalls (76/313). 76% of recalls were due to bacterial contamination (237/313), followed by unapproved components, labeling issues, and skin irritation. The 14 Class I recalls accounted for 1.9 million products in distribution.
Conclusions
Cosmetic recalls impacted millions of products and had the potential to cause serious harm. Dermatologists have the ability to strengthen public safety by reporting adverse events, encouraging recalls of harmful products, and lobbying through dermatology organizations for meaningful change to current cosmetic regulation.
https://ift.tt/2PR7R5H
An open‐label, single‐site study to evaluate the tolerability, safety, and efficacy of using a novel facial moisturizer for preparation and accelerated healing pre and post a single full‐face radiofrequency microneedling treatment
Summary
Background
Skincare cosmeceutical products have been shown to address intrinsic and extrinsic skin aging. Radiofrequency (RF) with microneedling is effective and safe in improving skin laxity and texture. Pairing skincare cosmeceutical products pre‐ and post‐procedure is beneficial as it enhances patient results, patient results, patient experience, and reduces patient downtime.
Objective
To evaluate the tolerability, safety, and efficacy of a multi‐ingredient anti‐aging facial moisturizer when applied pre‐ and post‐procedure consisting of a single RF microneedling treatment.
Method
Fifteen female patients, aged 37‐60, Fitzpatrick skin types I‐IV, with mild‐to‐moderate wrinkles were included in the study. Patients applied a multi‐ingredient anti‐aging facial moisturizer twice a day (morning and night) two weeks prior to RF microneedling and four weeks post‐RF microneedling (twice a day). At each time point, investigator objective assessment, self‐assessments, and clinical photography were taken.
Result
There were no adverse events as evaluated by the investigator. For this combined treatment and procedure patient scored comfort as the highest for satisfaction. Tolerability parameters erythema and edema were reported after RF microneedling treatment and were significant compared to the pre‐procedure timepoint. Eighty percent of patients showed an improvement in Glogau Wrinkle Scale, but improvement was not statistically significant between baseline and end of study. Improvements in all skin attributes (radiance, tone, smoothness, texture, redness, dryness, and overall appearance) were statistically significant at the end of the study. Self‐perceived skin attribute improvements included overall improvement, brightness, texture, pigmentation, redness, and tightness. The combination of the anti‐aging facial moisturizer and RF microneedling was recommended by the patients in this study.
Conclusion
This clinical study positively supports the hypothesis that combining the multi‐ingredient anti‐aging facial moisturizer pre‐ and post‐RF microneedling was safe and tolerable for the patients.
https://ift.tt/2RcYMky
SIG‐1273 protects skin against urban air pollution and when formulated in AgeIQ™ Night Cream anti‐aging benefits clinically demonstrated
Abstract
Background
SIG‐1273 is a novel cosmetic active that provides a broad spectrum of benefits to the skin. Considering the chronic skin exposure to pollution in urban areas, we sought to determine if SIG‐1273 could provide additional protection against skin aging by inhibiting pollutant‐induced cytotoxicity and inflammation.
Objective
Determine if SIG‐1273 possesses antipollution properties in vitro and evaluate the potential anti‐aging benefits of Age IQ™ Night Cream clinically in human subjects.
Methods
In vitro studies utilizing normal human epidermal keratinocytes (NHEKs), were co‐treated with urban dust (SRM 1649b) and SIG‐1273 (toxicity protection measured by MTS assay). A water‐soluble fraction of urban dust (UD‐WS) induces pro‐inflammatory cytokine release (IL‐8) from NHEKs (measured via ELISA). An 8‐week, 37‐subject clinical trial was performed with 0.05% SIG‐1273 formulated in Age IQ™ Night Cream and applied topically to assess its potential to reduce the appearance of aging.
Results
In vitro studies using NHEKs demonstrate SIG‐1273 protects against urban dust‐induced cell toxicity, reducing cell death by 66% and concentration dependently inhibits UD‐WS‐induced IL‐8 production (IC50 = 20 nmol/L), outperforming niacinamide, ascorbic acid, and α‐tocopherol, commonly used actives in antipollution skin‐care products. Clinical assessment of Age IQ™ Night Cream shows it is effective in improving the appearance of facial skin aging including fine lines and wrinkles, skin texture, skin clarity/brightness, and firmness/elasticity.
Conclusions
SIG‐1273, is demonstrated here for the first time to possess antipollution properties. Included as a key active ingredient in Age IQ™ Night Cream, this novel topical formulation provides benefits to individuals with aging skin.
https://ift.tt/2PR7Xdz
Effects of a topical lotion containing aminophylline, caffeine, yohimbe, l‐carnitine, and gotu kola on thigh circumference, skinfold thickness, and fat mass in sedentary females
Abstract
Background and objective
Topical aminophylline, caffeine, yohimbe, l‐carnitine, and gotu kola (Centella asiatica) may aid in reducing body fat. Lipoxyderm™ contains these ingredients and was used to test if fat loss of the thigh, in conjunction with a low intensity exercise program and restricted calorie intake, was enhanced via the topical application of this lotion.
Methods
This was a double‐blind, placebo‐controlled, within‐group study that investigated the effects of Lipoxyderm™ on thigh fat mass, circumference, and skinfold thickness. Seven participants underwent pre/post‐exercise testing for weight, bilateral thigh circumference/skinfold thickness, and body composition/thigh fat mass assessment via dual‐energy X‐ray absorptiometry. Participants followed a hypocaloric diet, walked 150 minutes/wk, and were randomly assigned to apply a placebo to one leg and Lipoxyderm™ to their other leg for 28 days. Separate two‐way mixed factorial repeated measures ANOVAs were used to compare the effects of Lipoxyderm™ to the placebo on thigh circumference, skinfold thickness, and fat mass.
Results
A significant time x group interaction was found for thigh circumference (F 1,6 = 18.2, P = 0.005), skinfold thickness (F 1,6 = 14.6, P = 0.009), and fat mass (F 1,6 = 37.1, P = 0.001).
Conclusions
A twice‐daily topical application of Lipoxyderm™ for 28 days compared to a placebo combined with a walking program and a restricted caloric intake is more effective at reducing thigh circumference (1.2 vs 0.8 cm), thigh skinfold thickness (3.7 vs 2.0 mm), and thigh fat mass (100.0 g vs 57.3 g).
https://ift.tt/2R7oIhj
Whole‐ and partial‐body cryotherapy in aesthetic dermatology: Evaluating a trendy treatment
Abstract
This manuscript addresses the use of whole‐ and partial‐body cryotherapy in aesthetic dermatology. Over the past several years, these have become trendy treatments that have been marketed for many purported benefits in overall skin appearance and skin health. With increased access through cryotherapy facilities and medical spas, whole‐ and partial‐body cryotherapy have grown in popularity. Unfortunately, many of the advertised claims have little, if any, scientific evidence behind them. Here, we summarize the data available in the literature. As trends evolve, clinicians should continue to be knowledgeable about them and their evidence in order to properly counsel patients appropriately.
https://ift.tt/2PTkqh4
3D‐printed Franz type diffusion cells
Abstract
Objective
Franz cells are routinely used to measure in vitro skin permeation of actives and must be inert to the permeant under study. The aim of the present work was to develop and manufacture transparent Franz‐type diffusion cells using 3D printing and test these using a range of model active compounds. The study also aims to identify the critical 3D printing parameters necessary for the process including object design, choice of printing resin, printout curing and post‐curing settings and introduction of model coatings.
Methods
Transparent Franz cells were constructed using an online computer aided design program and reproduced with different stereolithography 3D printers. The two acrylate‐based resins used for the fabrication process were a commercially available product and a polymer synthesised in‐house. Comparative studies between glass and 3D printed Franz cells were conducted with selected model actives: terbinafine hydrochloride (TBF), niacinamide (NIA), diclofenac free acid (DFA) and n‐methyl paraben (MPB). In preliminary studies, MPB showed the lowest recovery when exposed to the receptor compartment of 3D printed cells. Consequently, in vitro permeation studies were carried out using only MPB with polydimethylsiloxane (PDMS) membrane. RESULTS: A decrease in the amounts of selected compounds was observed for transparent 3D printed Franz cells compared to glass cells. MPB showed the lowest recovery (53.8 ± 13.1%) when compared with NIA (74.9 ± 4.0%), TBF (81.5 ± 12.0%) and DFA (90.2 ± 12.9%) after 72 h. Permeation studies conducted using 3D printed transparent cells with PDMS membrane also showed a decrease in MPB recovery of 51.4 ± 3.7% for the commercial resin and 94.4 ± 3.5% for the polymer synthesised in‐house, when compared to glass cells. Although hydrophobic coatings were subsequently applied to the 3D printed cells the same reduction in MPB concentration was observed in the receptor solution.
Conclusion
Transparent Franz cells were successfully prepared using 3D printing and were observed to be robust and leak‐proof. There are few resins currently available for preparation of transparent materials and incompatibilities between the actives investigated and the 3D printed cells were evident. Hydrophobic coatings applied as barriers to the printed materials did not prevent these interactions.
This article is protected by copyright. All rights reserved.
https://ift.tt/2Qk3a3P
Periostin concentrations in childhood-onset craniopharyngioma patients
Abstract
Purpose
Periostin is highly expressed in craniopharyngioma (CP)-associated fibroblasts and has been identified as a marker for non-alcoholic fatty liver disease (NAFLD). Half of CP patients with hypothalamic syndrome develop NAFLD. We hypothesized that periostin concentration is elevated in biological fluids of CP and associated with pathological hepatic parameters, indicating increased risk for NAFLD.
Methods
A cross-sectional study on 35 patients with sellar masses (SMP) recruited in the German Childhood Craniopharyngioma Registry (32 CP, 2 xanthogranuloma, 1 pilocytic astrocytoma), three short-statured patients with isolated growth hormone deficiency, five short-statured patients with normal findings in GH-stimulating tests and decreased insulin-like growth factor (IGF)-1 and seven healthy controls. Periostin was measured by Elisa in serum, urine and saliva.
Results
Periostin serum, urine and saliva concentrations in CP were similar to concentrations of the other groups. Hypothalamic involvement/hypothalamic lesions, degree of obesity as well as hepatic enzymes were not associated with elevated periostin concentrations. Due to low patient numbers with pathological hepatic parameters, missing imaging data on the degree of steatosis hepatis and the lack of histological proof of NAFLD, no definitive conclusions can be drawn from measured periostin concentrations in serum. Interestingly, the subgroup of patients with decreased IGF-1 levels showed elevated concentrations of serum periostin when compared with other groups.
Conclusions
In CP, periostin concentrations are not associated with known risk factors for NAFLD such as hepatic and metabolic parameters, obesity and hypothalamic lesions. Accordingly, periostin does not seem to be a suitable marker for NAFLD in CP.
https://ift.tt/2r1eVhc
Εγγραφή σε:
Αναρτήσεις (Atom)
-
Ειδοποίηση Μελετητή:[ ωτα ] [HTML] Gender, identity and material: Film screening C Brand - 2017 ftypM4V *M4V M4A mp42isom*a┌moovlmvhd...
-
Publication date: September 2017 Source: Free Radical Biology and Medicine, Volume 110 Author(s): Lucía Fernández-del-Río, Anish Nag, Elen...
