Human scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate—A perplexing perspective

Summary

Several journal reports, reviews, and commentaries over the last 20‐25 years have pointed out the controversy attached to 17β‐estradiol's inhibitory or stimulatory influence on hair follicle growth/cycling citing rodent (murine) and human results. While 17β‐estradiol is the most potent sex steroid hormone in the body and has almost equal affinity for estrogen receptor (ER) alpha (α) and beta (β), there appears to be specific ER‐mediated effects on scalp hair follicles/growth, etc. Additionally, the newly discovered G protein‐coupled estrogen receptor (GPR30 or GPER) and the orphan receptor, estrogen‐related receptor (ERR) gamma (γ), in skin and other tissue sites have potential impacts of how estrogens via these receptors may alter scalp hair characteristics, but this remains to be elucidated. Conversely, the negative impact of the 5α‐reductase enzyme and its steroid product, 5α‐dihydrotestosterone, on scalp hair growth is clear. Less clear is how 17β‐estradiol is stimulatory in some scalp hair studies, but inhibitory in others. This brief summary examines the potential influences of steroidogenesis via aromatase (estrogen biosynthesis) and 5α‐reductase expression, their enzyme activities, and steroid products along with the concepts of how steroid acute regulatory protein (StAR) and estrone sulfate may be involved in the complex hormonal, cellular/molecular signaling cascade of the hair follicle in growth and cycling.

http://bit.ly/2tpUE6s

Lungensonografie für Anästhesie, Intensiv- und Notfallmedizin

Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54: 108-127
DOI: 10.1055/a-0664-5700

Die Lungensonografie ist in der Intensiv- und Notfallmedizin ein unterschätztes Werkzeug: Bei bestimmten klinischen Fragestellungen ist ihre Sensitivität drastisch höher als die der Röntgen-Thoraxuntersuchung 1. Ein standardisierter Untersuchungsgang verbessert dabei die Untersuchungsqualität 2. Dieser Artikel vermittelt Grundlagenwissen der Lungensonografie und stellt die Überlegenheit des Ultraschalls gegenüber Röntgenverfahren heraus.
[...]

Georg Thieme Verlag KG Stuttgart · New York

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http://bit.ly/2UVObfc

Ultraschall in AINS

Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54: 88-89
DOI: 10.1055/a-0805-2279

Georg Thieme Verlag KG Stuttgart · New York

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http://bit.ly/2EcLiku

Extrakorporale kardiopulmonale Reanimation: Datenlage bis heute unklar

Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54: 85-86
DOI: 10.1055/a-0823-5785

Georg Thieme Verlag KG Stuttgart · New York

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http://bit.ly/2V1M5KJ

Kaffee, Kippe, Kaugummi – Mythen und Fakten zur präoperativen Nüchternheit

Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54: 142-145
DOI: 10.1055/s-0043-124943

Zur Reduktion des Aspirationsrisikos gelten strikte Vorgaben für präoperative Nüchternzeiten. Für klare Flüssigkeiten (2 Stunden) und feste Nahrung (6 Stunden) sind diese eindeutig definiert; der Einfluss von Kaffee, Rauchen und Kaugummi wird dagegen kontrovers diskutiert. Dieser Beitrag zeigt, welche Mythen zur präoperativen Nüchternheit bestehen und durch welche Fakten sich das Risiko verlässlich einordnen lässt.
[...]

Georg Thieme Verlag KG Stuttgart · New York

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http://bit.ly/2Ef1Fxb

Driving Pressure – ein neuer/alter Parameter zur Beatmungsoptimierung?

Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54: 85-85
DOI: 10.1055/a-0823-5844

Georg Thieme Verlag KG Stuttgart · New York

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http://bit.ly/2UZXSZV

Die fokussierte transthorakale Echokardiografie in der perioperativen Versorgung

Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54: 90-106
DOI: 10.1055/a-0586-6146

Mithilfe der fokussierten transthorakalen Echokardiografie (TTE) erhalten wir rasch und nichtinvasiv aktuelle Informationen zum hämodynamischen Status eines Patienten. Diese können nachfolgend unsere aktuelle Therapie und dadurch unser Risikomanagement beeinflussen. Postoperativ hat sich die TTE als Untersuchungsmethode im Aufwachraum und auf der Intensivstation bewährt, um lebensbedrohliche Ursachen für eine Kreislaufdepression zeitnah zu diagnostizieren. Akutpathologika wie eine Perikardtamponade oder die fulminante Pulmonalarterienembolie können so schnell erfasst und evtl. auch zeitintensive Transporte in eine CT vermieden werden. Auch präoperativ kann der Einsatz der TTE sinnvoll sein zur Beurteilung des Volumenstatus, der Pumpfunktion oder hämodynamisch relevanter Vitien. Vor allem bei Operationen mit hohem perioperativem Komplikationsrisiko können diese Erkenntnisse mit in eine „goal-directed therapy" einfließen. Entsprechende Algorithmen für ein erweitertes hämodynamisches Monitoring und das Volumenmanagement existieren bereits in vielen Bereichen – sie werden aber häufig nicht konsequent umgesetzt und in die Abläufe der eigenen Klinik implementiert. Mit diesem Artikel legen wir Nutzen und Relevanz der hämodynamischen Evaluation mittels TTE in jeder Phase der Patientenversorgung dar. Darüber hinaus stellen wir einen möglichen Algorithmus für die Versorgung kritisch kranker Patienten vor, der auf den wichtigsten transthorakalen Untersuchungen und hämodynamischen Messverfahren basiert. Er soll im klinischen Alltag und insbesondere im Bereitschaftsdienst eine Hilfestellung für den sinnvollen Einsatz der TTE bieten.
[...]

Georg Thieme Verlag KG Stuttgart · New York

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http://bit.ly/2EdNw38

Spinalanästhesie mit Chloroprocain 1% zeigt Vorteile bei ambulanten Arthroskopien

Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54: 86-87
DOI: 10.1055/a-0823-5577

Georg Thieme Verlag KG Stuttgart · New York

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http://bit.ly/2UZXM4v

Abdominelle Notfallsonografie in der Intensiv- und Akutmedizin

Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54: 128-141
DOI: 10.1055/a-0585-5237

Die sonografischen Untersuchungstechniken unterstützen die Point-of-Care-Diagnostik (POC-Diagnostik) bei akutmedizinischen Fragestellungen. Für den Intensiv- und Notfallmediziner gilt: Kenntnisse und Fertigkeiten einer fokussierten Sonografie sind unabdingbar. Dieser Artikel beleuchtet die Optionen der abdominellen Notfallsonografie und gibt praktische Hilfestellung.
[...]

Georg Thieme Verlag KG Stuttgart · New York

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http://bit.ly/2Ed62sx

Gewalt in der Notfallmedizin – gegenwärtiger Stand in Deutschland

Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54: 146-154
DOI: 10.1055/s-0043-112189

Hintergrund In den letzten Jahren werden Mitarbeiter von Rettungsdiensten und Notaufnahmen immer häufiger Opfer von gewalttätigen Übergriffen während ihres Dienstes. Jedoch wird die Erfassung von Häufigkeiten, Arten, Ursachen, Täterprofilen sowie möglichen Lösungsansätzen und Schutzmaßnahmen in Deutschland bisher – im Vergleich zum angloamerikanischen Sprachraum – eher stiefmütterlich behandelt. Ziel Das Ziel dieser Arbeit war eine weitgehende Erfassung der bisher vorliegenden aktuellen Daten der letzten Jahre, um einen zusammenfassenden Überblick über die Situation in Deutschland geben zu können. Ergebnisse Es liegen nur sehr wenige Arbeiten aus Deutschland zu diesem Thema vor. Die gefundenen Arbeiten zeigten, dass Gewalt im Rettungsdienst und in der Notaufnahme nicht nur ein Problem im angloamerikanischen Sprachraum ist. Bis zu 90% der Studienteilnehmer einer Befragung von Rettungsdienstmitarbeitern und 75% der teilnehmenden Mitarbeiter aus Notaufnahmen gaben an, in den letzten Monaten vor der Befragung Opfer von verbaler und/oder physischer Gewalt geworden zu sein. Die Mehrheit der Studienteilnehmer (je nach Studie zwischen 60 und 80%) fühlt sich gar nicht bis unzureichend auf aggressives und gewalttätiges Verhalten vorbereitet und wünscht sich professionelle regelmäßige Weiterbildung in Deeskalationstechniken und Selbstverteidigung. Auch die ständige Anwesenheit von Sicherheitsdiensten wurde zur Verminderung gewaltsamer Übergriffe auf Mitarbeiter durch Studienteilnehmer als sinnvoll erachtet. Um konkretere Aussagen treffen zu können, bedarf es weiterer prospektiver Multicenterstudien.
[...]

Georg Thieme Verlag KG Stuttgart · New York

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http://bit.ly/2UZXBWT

Massiver Informationsverlust bei Übergaben auf Intensivstation!

Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54: 84-85
DOI: 10.1055/a-0823-5728

Georg Thieme Verlag KG Stuttgart · New York

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http://bit.ly/2EdNtEu

Effects of channel morphology on nitrate retention in a headwater agricultural stream in Lake Chaohu Basin, China

Abstract

Five field tracer experiments and relevant detailed investigations of physical characterizations were conducted to investigate the effects of channel geomorphic settings on nitrate uptake efficiency on a 310-m long geomorphically distinct stream reach in a headwater agricultural stream in Hefei District, Lake Chaohu Basin. The model-fitted parameters from the one-dimensional transport with inflow and storage model were used to estimate the transient storage metric ( \( {F}_{\mathrm{med}}^{200} \) ) and determine the total nitrate uptake coefficient (k) for the study reach. And then, a nutrient spiraling approach was applied to reach-scale nitrate uptake estimates (S_w, V_f, and U). The results showed that the main channel was the major contributor to nitrate uptake retention, and the higher geomorphic complexity might result in better nitrate uptake efficiency. The partial least squares regression (PLSR) analysis showed strong correlations between the independent variables as geomorphic settings, Reynolds number and transient storage, and the dependent variables as nitrate uptake metrics, which further underscored the importance of stream physical characteristics on measurement of stream nitrate uptake.

http://bit.ly/2DJMieE

A novel nano zero-valent iron biomaterial for chromium (Cr 6+ to Cr 3+ ) reduction

Abstract

This research work aims to develop a biomaterial entrapped with iron nanoparticles by green synthesis method in which biomass act as both reducing and capping agent. Iron nanoparticles embedded in Citrus limetta peels were characterised using ICP-MS for determination of metal loading, XRD, XPS for crystallinity and oxidation states, TEM followed by FESEM-EDS for particle size and morphology. Sizes of nanoparticles were found to be in the range of 4–70 nm. Batch experiments were conducted to study the effect of different parameters such as contact time, amount of biomaterial and volume of chromium(VI) solution for 2500 mg L⁻¹ of Cr(VI). Complete reduction was attained for a contact time of 5 min with 1.5 g of biomaterial for initial concentration of 2500 mg L⁻¹. The experimental results inferred that 1 g of biomaterial completely reduced 33 mg of hexavalent Cr to trivalent Cr. XRD and XPS revealed that iron nanoparticles are in amorphous form while XPS confirms Fe⁰ state. The transition of Fe⁰ to Fe²⁺/Fe³⁺ during the treatment with chromium solution confirms the reduction of Cr⁶⁺ to Cr³⁺.

http://bit.ly/2SBHan1

Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles

Abstract

The advent of biotechnology provided the synthesis of nanoproducts with diverse applications in the field of medicine, agriculture, food, among others. However, the toxicity of many nanoparticles (NP) currently used, which can penetrate natural systems and impact organisms, is not known. Thus, in this study, we evaluated whether the short exposure (5 days) to low concentrations of chitosan-coated zein nanoparticles (ZNP-CS) (0.2 ng/kg, 40 ng/kg, and 400.00 ng/kg) was capable of causing behavioral alterations compatible with cognitive deficit, as well as anxiety and depression-like behavior in Swiss mice. However, we observed an anxiogenic effect in the animals exposed to the highest ZNP-CS concentration (400.00 ng/kg), without locomotor alterations suggestive of sedation or hyperactivity in the elevated plus maze (EPM) test. We also observed that the ZNP-CS caused depressive-like behavior, indicated by the longer immobile time in the tail suspension test and the animals exposed to ZNP-CS presented deficit in recognition of the new object, not related to locomotor alteration in this test. To the best of our knowledge, this is the first report of the neurotoxicity of ZNP in a mammal animal model, contributing to the biological safety assessment of these nanocomposites.

http://bit.ly/2DGaezA

Preliminary report of microwave ablation for the primary papillary thyroid microcarcinoma: a large-cohort of 185 patients feasibility study

Abstract

Purpose

To assess the safety and efficacy of microwave ablation (MWA) for primary papillary thyroid microcarcinoma (PTMC) with a large sample of 185 patients.

Methods

A total of 185 patients underwent MWA for 206 primary PTMC nodules. They received ultrasound follow-up at 1, 3, 6, and 12 months after MWA and every 6 months thereafter. Nodule volumes were calculated at each follow-up and compared with those before MWA. Additionally, the volume reduction rate (VRR) of the nodules was calculated. Patients' thyroid functions were tested before and 1 month after MWA.

Results

The mean follow-up time of the 185 patients was 20.7 ± 8.8 months (range 12–36 months). During the follow-up period, the mean volume of the 206 nodules was 100.1 ± 92.9 mm³ (range 3.6–423.9) before MWA, which decreased to 2.2 ± 5.6 mm³ (range 0–20.3 mm³) after MWA (P = 0.000). The mean VRR of the nodules was 98.65 ± 3.60% after MWA (range 83.85–100%). One hundred and seventy four of 206 nodules (84.5%) were fully absorbed. Compared with the preoperative results, no significant variation in thyroid function was observed 1 month after MWA. Thirty-eight patients (20.5%) had different types of complications, ranging from minor to major. Five patients (2.7%) had hoarseness, 11 patients (5.9%) had bleeding, 21 patients (11.4%) had earache or toothache, and one patient had another lesion 1 month after MWA.

Conclusions

This preliminary study suggests that MWA is safe and effective in the treatment of primary PTMC and offers a new alternative for clinical treatment.

http://bit.ly/2X5CuV1

Preliminary report of microwave ablation for the primary papillary thyroid microcarcinoma: a large-cohort of 185 patients feasibility study

Abstract

Purpose

To assess the safety and efficacy of microwave ablation (MWA) for primary papillary thyroid microcarcinoma (PTMC) with a large sample of 185 patients.

Methods

A total of 185 patients underwent MWA for 206 primary PTMC nodules. They received ultrasound follow-up at 1, 3, 6, and 12 months after MWA and every 6 months thereafter. Nodule volumes were calculated at each follow-up and compared with those before MWA. Additionally, the volume reduction rate (VRR) of the nodules was calculated. Patients' thyroid functions were tested before and 1 month after MWA.

Results

The mean follow-up time of the 185 patients was 20.7 ± 8.8 months (range 12–36 months). During the follow-up period, the mean volume of the 206 nodules was 100.1 ± 92.9 mm³ (range 3.6–423.9) before MWA, which decreased to 2.2 ± 5.6 mm³ (range 0–20.3 mm³) after MWA (P = 0.000). The mean VRR of the nodules was 98.65 ± 3.60% after MWA (range 83.85–100%). One hundred and seventy four of 206 nodules (84.5%) were fully absorbed. Compared with the preoperative results, no significant variation in thyroid function was observed 1 month after MWA. Thirty-eight patients (20.5%) had different types of complications, ranging from minor to major. Five patients (2.7%) had hoarseness, 11 patients (5.9%) had bleeding, 21 patients (11.4%) had earache or toothache, and one patient had another lesion 1 month after MWA.

Conclusions

This preliminary study suggests that MWA is safe and effective in the treatment of primary PTMC and offers a new alternative for clinical treatment.

http://bit.ly/2X5CuV1

Detection of outliers in pollutant emissions from the Soto de Ribera coal-fired power plant using functional data analysis: a case study in northern Spain

Abstract

For more than a century, air pollution has been one of the most important environmental problems in cities. Pollution is a threat to human health and is responsible for many deaths every year all over the world. This paper deals with the topic of functional outlier detection. Functional analysis is a novel mathematical tool employed for the recognition of outliers. This methodology is applied here to the emissions of a coal-fired power plant. This research uses two different methods, called functional high-density region (HDR) boxplot and functional bagplot. Please note that functional bagplots were developed using bivariate bagplots as a starting point. Indeed, they are applied to the first two robust principal component scores. Both methodologies were applied for the detection of outliers in the time pollutant emission curves that were built using, as inputs, the discrete information available from an air quality monitoring data record station and the subsequent smoothing of this dataset for each pollutant. In this research, both new methodologies are tested to detect outliers in pollutant emissions performed over a long period of time in an urban area. These pollutant emissions have been treated in order to use them as vectors whose components are pollutant concentration values for each observation made. Note that although the recording of pollutant emissions is made in a discrete way, these methodologies use pollutants as curves, identifying the outliers by a comparison of curves rather than vectors. Then, the concept of outlier goes from being a point to a curve that employs the functional depth as the indicator of curve distance. In this study, it is applied to the detection of outliers in pollutant emissions from a coal-fired power plant located on the outskirts of the city of Oviedo, located in the north of Spain and capital of the Principality of Asturias. Also, strengths of the functional methods are explained.

http://bit.ly/2GLycwv

Management immunologischer Nebenwirkungen von Patienten, die mit Immun-Checkpoint-Inhibitoren behandelt werden: ASCO Clinical Practice Guideline Summary

http://bit.ly/2SHw6oE

Association and gene–gene interaction analyses for polymorphic variants in CTLA-4 and FOXP3 genes: role in susceptibility to autoimmune thyroid disease

Abstract

Purpose

Polymorphic variants of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and forkhead box protein P3 (FOXP3) genes are implicated in dysregulated immune homeostasis and autoimmune disorders. We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thyroid disease (AITD), inclusive of Hashimoto's thyroiditis (HT) and Graves' disease (GD) in South-Indian population.

Methods

A total of 355 AITD subjects (comprising 275 HT and 80 GD) and 285 randomly selected age- and sex-matched control subjects were genotyped for the aforementioned polymorphisms by PCR-RFLP method.

Results

The rs231775 "G" allele was preponderant in HT and GD subjects when compared with controls and exerted a dominant influence on the susceptibility to HT (p = 0.009) and GD (p = 0.02), respectively. There was no allelic association of rs3761548 and rs3761549 polymorphisms with AITD susceptibility, albeit a significant difference in genotype distribution with respect to rs3761549. Haplotype analysis revealed an increased frequency of rs3761548 "C"–rs3761549 "T" in HT and GD subjects, thereby associating it with disease predisposition (p = 0.03). Epistatic interaction analysis by multifactor dimensionality reduction approach revealed redundancy between CTLA-4 and FOXP3 genes in influencing the susceptibility to AITD.

Conclusions

The genetic variation in CTLA-4 gene with reference to rs231775 polymorphism contributes to an increased predisposition to HT and GD. Also, in conjunction with FOXP3 gene variants it seems to influence the susceptibility to HT and GD respectively. The significance of these findings in combination with antithyroid antibody screening could plausibly contribute towards meticulous case-finding for effective treatment of HT and GD.

http://bit.ly/2SUEBM9

Association and gene–gene interaction analyses for polymorphic variants in CTLA-4 and FOXP3 genes: role in susceptibility to autoimmune thyroid disease

Abstract

Purpose

Polymorphic variants of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and forkhead box protein P3 (FOXP3) genes are implicated in dysregulated immune homeostasis and autoimmune disorders. We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thyroid disease (AITD), inclusive of Hashimoto's thyroiditis (HT) and Graves' disease (GD) in South-Indian population.

Methods

A total of 355 AITD subjects (comprising 275 HT and 80 GD) and 285 randomly selected age- and sex-matched control subjects were genotyped for the aforementioned polymorphisms by PCR-RFLP method.

Results

The rs231775 "G" allele was preponderant in HT and GD subjects when compared with controls and exerted a dominant influence on the susceptibility to HT (p = 0.009) and GD (p = 0.02), respectively. There was no allelic association of rs3761548 and rs3761549 polymorphisms with AITD susceptibility, albeit a significant difference in genotype distribution with respect to rs3761549. Haplotype analysis revealed an increased frequency of rs3761548 "C"–rs3761549 "T" in HT and GD subjects, thereby associating it with disease predisposition (p = 0.03). Epistatic interaction analysis by multifactor dimensionality reduction approach revealed redundancy between CTLA-4 and FOXP3 genes in influencing the susceptibility to AITD.

Conclusions

The genetic variation in CTLA-4 gene with reference to rs231775 polymorphism contributes to an increased predisposition to HT and GD. Also, in conjunction with FOXP3 gene variants it seems to influence the susceptibility to HT and GD respectively. The significance of these findings in combination with antithyroid antibody screening could plausibly contribute towards meticulous case-finding for effective treatment of HT and GD.

http://bit.ly/2SUEBM9