Creating Age Asymmetry: Consequences of Inheriting Damaged Goods in Mammalian Cells

Publication date: Available online 4 October 2016
Source:Trends in Cell Biology
Author(s): Darcie L. Moore, Sebastian Jessberger
Accumulating evidence suggests that mammalian cells asymmetrically segregate cellular components ranging from genomic DNA to organelles and damaged proteins during cell division. Asymmetric inheritance upon mammalian cell division may be specifically important to ensure cellular fitness and propagate cellular potency to individual progeny, for example in the context of somatic stem cell division. We review here recent advances in the field and discuss potential effects and underlying mechanisms that mediate asymmetric segregation of cellular components during mammalian cell division.



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