Ketamine inhalation

<span class="paragraphSection">Editor—Usually, ketamine is dissolved in saline and administered i.v. or i.m. Alternative routes, such as oral, nasal, and rectal administration, have been described for less resource-consuming and painless administration.<a href="#aew457-B1" class="reflinks">¹</a><a href="#aew457-B2" class="reflinks">²</a> We explored the safety and feasibility of delivery of ketamine by inhalation. Advantages of this route include rapid delivery and absorption into the systemic circulation and the possibility of ketamine administration outside the hospital setting because no i.v. access line is required. The study was performed in healthy volunteers of either sex (aged 18–40 yr, BMI <30 kg m⁻²) after approval by the local human ethics committee and after receiving written informed consent from participants. The study was registered at the Dutch trial registry (NTR 5358).</span>

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