Autoimmunity in Guillain-Barré syndrome associated with Zika virus infection and beyond

Publication date: Available online 13 February 2017
Source:Autoimmunity Reviews
Author(s): Carlos A. Pinto-Díaz, Yhojan Rodríguez, Diana M. Monsalve, Yeny Acosta-Ampudia, Nicolás Molano-González, Juan-Manuel Anaya, Carolina Ramírez-Santana
Autoimmune diseases share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities among them as well as their familial clustering. Guillain-Barré syndrome (GBS), an autoimmune peripheral neuropathy, has been recently associated with Zika virus (ZIKV) infection. Based on a series of cases, this review article provides a comparative analysis of GBS associated with ZIKV infection, contrasted with the general characteristics of GBS in light of the autoimmune tautology, including gender differences in prevalence, subphenotypes, polyautoimmunity, familial autoimmunity, age at onset, pathophysiology, ecology, genetics, ancestry, and treatment.



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