Small-Molecule RORγt Antagonists: One Stone Kills Two Birds

Publication date: Available online 28 February 2017
Source:Trends in Immunology
Author(s): Chao Zhong, Jinfang Zhu
Although small-molecule thymus-specific isoform of retinoic acid receptor-related orphan nuclear receptor γ (RORγt) antagonists suppressing interleukin (IL)-17-producing T helper (Th17) cells are widely reported, the effect of these molecules on other RORγt-expressing cells is unknown. However, a new study reports that RORγt inhibition in CD4⁺CD8⁺ thymocytes resulted in skewed T cell repertoire, contributing to a reduction in the frequency of self-reactive T cells and resistance to autoimmunity.



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