Antimicrobial resistance and molecular characteristics of methicillin-resistant Staphylococcus aureus isolates from child patients of high-risk wards in Shenzhen, China.

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Antimicrobial resistance and molecular characteristics of methicillin-resistant Staphylococcus aureus isolates from child patients of high-risk wards in Shenzhen, China.

Jpn J Infect Dis. 2017 Feb 28;:

Authors: Qin Y, Wen F, Zheng Y, Zhao R, Hu Q, Zhang R

Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) causes high rates of mortality and a substantial burden to health systems worldwide. Here, we investigated the antimicrobial susceptibility and molecular characteristics of MRSA isolated from children treated at Shenzhen Children's Hospital. 140 MRSA strains were characterized by antimicrobial susceptibility testing. We further performed spa typing, multilocus sequence typing (MLST), staphylococcal cassette chromosome mec (SCCmec), pvl gene and pulsed-field gel electrophoresis (PFGE). These MRSA strains were sensitive to most non-β-lactam antimicrobial agents. ST59 was the most common MLST lineage (54.3%). Most MRSA isolates belonged to SCCmec IV (64.3%) and V (22.8%). The MRSA-ST59-SCCmec IV-t437 clone was found to be predominant, infecting 28.6% of patients studied. Moreover, 50.7% of MRSA isolates were pvl positive. We thus report preliminary data on the prevalence and distribution of MRSA genotypes in Shenzhen Children's Hospital. These findings characterize the MRSA colonization dynamics in child patients in China, and may aid design of strategies to prevent MRSA infection and dissemination.

PMID: 28250256 [PubMed - as supplied by publisher]

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