Cutting Edge in IFN Regulation: Inflammatory Caspases Cleave cGAS

Publication date: 21 March 2017
Source:Immunity, Volume 46, Issue 3
Author(s): Simon Heidegger, Tobias Haas, Hendrik Poeck
Caspases have important functions beyond their established role in driving inflammation and apoptosis. In this issue of Immunity, Wang et al. (2017) demonstrate that inflammasome-triggered caspases cleave and inactivate the DNA sensor cGAS, thus restricting the type I interferon response to cytosolic DNA.

Teaser

Caspases have important functions beyond their established role in driving inflammation and apoptosis. Wang et al. (2017) demonstrate that inflammasome-triggered caspases cleave and inactivate the DNA sensor cGAS, thus restricting the type I interferon response to cytosolic DNA.


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