Effects of polymorphisms identified in genome-wide association studies of never-smoking females on the prognosis of non-small cell lung cancer

Publication date: Available online 20 March 2017
Source:Cancer Genetics
Author(s): Seung Soo Yoo, Hyo-Gyoung Kang, Jin Eun Choi, Sook Kyung Do, Won Kee Lee, Sun Ha Choi, So Yeon Lee, Shin Yup Lee, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Yangki Seok, Eungbae Lee, Moon Soo Kim, Jong mog Lee, Hyun-Ju Cho, In-Jae Oh, Young-Chul Kim, Sukki Cho, Sanghoon Jheon, Chi Young Jung, Mi-Hyun Kim, Min Ki Lee, Jae Yong Park
A number of genome-wide association studies have reported several variants that influence the risk of lung cancer in never-smoking females. We evaluated the impact of these variants on survival outcome in never-smoking females with non-small cell lung cancer (NSCLC). In total, 510 never-smoking females with NSCLC who underwent curative surgery were enrolled. Eleven variants associated with lung cancer susceptibility in never-smoking females, were genotyped and their associations with survival outcome were analyzed. Among these 11 variants, TP63 rs7631358 and CSF1R rs10079250 affected survival outcomes. TP63 rs7631358 G>A was associated with a relatively worse overall survival (under a dominant model; hazard ratio = 2.31, 95% confidence interval = 1.18 – 4.52, P = 0.01). CSF1R rs10079250 A>G was associated with a relatively better disease-free survival (under a codominant model; hazard ratio = 0.70, 95% confidence interval = 0.53 – 0.93, P = 0.01). These results suggest that TP63 rs7631358 G>A and CSF1R rs10079250 A>G may affect the prognosis of NSCLC in never-smoking females, as well as the risk of lung cancer.



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