Cleaning House: Selective Autophagy of Organelles

Publication date: 10 April 2017
Source:Developmental Cell, Volume 41, Issue 1
Author(s): Allyson L. Anding, Eric H. Baehrecke
The selective clearance of organelles by autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. Removal of damaged organelles clears the cell of potentially toxic byproducts and enables reuse of organelle components for bioenergetics. Thus, defects in organelle clearance may be detrimental to the health of the cells, contributing to cancer, neurodegeneration, and inflammatory diseases. Organelle-specific autophagy can clear mitochondria, peroxisomes, lysosomes, ER, chloroplasts, and the nucleus. Here, we review our understanding of the mechanisms that regulate the clearance of organelles by autophagy and highlight gaps in our knowledge of these processes.

Teaser

The selective clearance of organelles by autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. Defects in organelle clearance can be detrimental and contribute to cancer, neurodegeneration, and inflammatory diseases. Anding and Baehrecke review the understanding of the regulation of organelle clearance by autophagy.


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