Molecular assessment of protective effect of Vitex negundo in ISO induced myocardial infarction in rats

Publication date: August 2017
Source:Biomedicine & Pharmacotherapy, Volume 92
Author(s): Maruthi Prasad E., Ramgopal Mopuri, Madhusudana Pulaganti, Mohammed Abdul Kareem, Md. Shahidul Islam, Dase Gowda K.R, Mackraj Irene, Yingli Lu, Lakshmi Devi Kodidhela
Myocardial infarction (MI) is the one of the major causes of death worldwide, however the molecular mechanisms hidden under this disease conditions remain unknown. This demands serious attention to unravel the molecular mechanisms to identify the therapeutic strategies either to prevent or to control MI. Ayurveda is becoming one of the best alternatives for the modern medicines. On the other hand, Vitex negundo is one of the medicinally important plants used for various diseases and to date, its cardioprotective role is not fully elucidated. In the present study, we made an attempt to understand the cardiac signaling cascade of Akt1 and NF-κB in isoproterenol (ISO)-induced MI, and targeting these signaling molecules by using V. negundo leaf ethanolic extract (VNE). Our findings demonstrate that VNE significantly protects the ISO-induced MI by regulating NF-κB and Akt1experssion in rats.

Graphical abstract

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