Proteostatic and Metabolic Control of Stemness

Publication date: 4 May 2017
Source:Cell Stem Cell, Volume 20, Issue 5
Author(s): Laura García-Prat, Pedro Sousa-Victor, Pura Muñoz-Cánoves
Adult stem cells, particularly those resident in tissues with little turnover, are largely quiescent and only activate in response to regenerative demands, while embryonic stem cells continuously replicate, suggesting profoundly different regulatory mechanisms within distinct stem cell types. In recent years, evidence linking metabolism, mitochondrial dynamics, and protein homeostasis (proteostasis) as fundamental regulators of stem cell function has emerged. Here, we discuss new insights into how these networks control potency, self-renewal, differentiation, and aging of highly proliferative embryonic stem cells and quiescent adult stem cells, with a focus on hematopoietic and muscle stem cells and implications for anti-aging research.

Teaser

García-Prat et al. discuss new insights into how metabolism, mitochondrial dynamics, and protein homeostasis (proteostasis) regulate embryonic and adult stem cell function and the implications for anti-aging research.


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