Trends in antiepileptic drug use in children and adolescents with epilepsy

Publication date: Available online 29 May 2017
Source:Pediatric Neurology
Author(s): Xinyue Liu, Paul R. Carney, Regina Bussing, Richard Segal, Linda B. Cottler, Almut G. Winterstein
ObjectiveTo describe the trends in antiepileptic drug (AED) use in children and adolescents with epilepsy in the US.MethodsThis is a cross-sectional study based on Medicaid Analytic eXtract dataset from 26 US states. Children and adolescents 3-18 years of age with at least one year continuous Medicaid fee-for-service (FFS) coverage after the second outpatient or the first inpatient diagnosis of epilepsy in each calendar year during 1999-2009 were included in the study; therefore, eleven cohorts were established. A patient was defined as being exposed to a specific AED if he/she had at least one day supply of the AED during the 1-year follow-up period. The annual prevalence of AEDs was reported, stratified by gender and age. The trends in AED use were evaluated through linear regression.ResultsThe sample sizes of the eleven cohorts ranged between 17,304 and 22,672. The annual prevalence of valproic acid use declined from 42.4% in 1999 to 26.5% in 2009, and the prevalence of carbamazepine use declined from 37.1% to 10.2%. Meanwhile, the prevalence of levetiracetam use increased from 5.1% to about 32.0% in 2009, and the prevalence of oxcarbazepine use increased from 1.3% to 19.1%. Since 2008, levetiracetam (29.6%) has replaced valproic acid (27.8%) to be the most commonly used AED in children and adolescents with epilepsy. The prevalence of diazepam use increased from 11.6% to 28.1%.SignificanceCompared with first- and second-generation AEDs, third-generation AEDs have fewer adverse side effects, resulting in increased patient treatment adherence. Equally important is the economic impact of these newer AEDs. This first-of-its-kind study underscores the need for large database studies that objectively assess the cost-effectiveness of third-generation AEDs versus first- and second-generation AEDs in the treatment of childhood epilepsy.



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