A pilot study comparing histological and immunophenotypic patterns in stage 4 skin graft versus host disease from toxic epidermal necrolysis

Abstract

Since the inception of bone marrow transplantation, clinicians have sought to distinguish stage 4 skin graft versus host disease (GVHD) from toxic epidermal necrolysis (TEN).^1–3 In certain contexts, it can be difficult to discern among these two entities, both clinically and histologically. However, the distinction is critical because both diseases can be life-threatening and their respective management and prognosis differ.

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