Incidence of Parathyroid Disorders in an Indian Adult Male Population: A 25 year follow up study

Abstract

Context and Objective

Detailed information on the epidemiology of parathyroid disorders in India is lacking. Most of the available data pertain to primary hyperparathyroidism (PHPT) rather than the overall burden of parathyroid disorders. We studied the incidence of parathyroid disorders in a cohort of service personnel followed for a long duration.

Design, setting and patients

The data for this retrospective, descriptive epidemiological study were derived from the electronic medical records (EMR) of health care personnel enrolled between 1990 and 2015. Subjects were recruited between the ages of 17 and 20 years in good health and the data pertaining to parathyroid disorders were derived from the EMR.

Main outcomes measures

We calculated the incidence rates per person-years of parathyroid disorders using appropriate statistical methods.

Results

Our analysis includes 51,217 participants (median age 33, range 17 – 54 years) with a mean follow up of 12.5 years. Yearly evaluation of the data gave a cumulative follow up duration of 613,925 person-years. PHPT was diagnosed in 37 and hypoparathyroidism in 16 patients, giving incidence rates of 6 and 2.6 per 100,000 person-years respectively. Only one patient was diagnosed with pseudohypoparathyroidism (0.16 per 100,000 person-years). Out of the 37 patients with PHPT, 16 (43%) developed post-surgical hypoparathyroidism.

Conclusion

Our cohort had a low incidence of PHPT when compared to western populations. Long term epidemiological studies are essential to identify the demographic trends of metabolic bone disorders in India.

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