Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer

Publication date: Available online 12 June 2017
Source:Microbes and Infection
Author(s): Farhoud Faraji, Munfarid Zaidi, Carole Fakhry, Daria A. Gaykalova
This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.



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