Phosphate Starvation-Dependent Iron Mobilization Induces CLE14 Expression to Trigger Root Meristem Differentiation through CLV2/PEPR2 Signaling

Publication date: 5 June 2017
Source:Developmental Cell, Volume 41, Issue 5
Author(s): Dolores Gutiérrez-Alanís, Lenin Yong-Villalobos, Pedro Jiménez-Sandoval, Fulgencio Alatorre-Cobos, Araceli Oropeza-Aburto, Javier Mora-Macías, Federico Sánchez-Rodríguez, Alfredo Cruz-Ramírez, Luis Herrera-Estrella
Low inorganic phosphate (Pi) availability causes terminal differentiation of the root apical meristem (RAM), a phenomenon known as root meristem exhaustion or determined growth. Here, we report that the CLE14 peptide acts as a key player in this process. Low Pi stress induces iron mobilization in the RAM through the action of LPR1/LPR2, causing expression of CLE14 in the proximal meristem region. CLV2 and PEPR2 receptors perceive CLE14 and trigger RAM differentiation, with concomitant downregulation of SHR/SCR and PIN/AUXIN pathway. Our results reveal multiple steps of the molecular mechanism of one of the most physiologically important root nutrient responses.

Graphical abstract

Teaser

Phosphorus limitation profoundly affects root development in Arabidopsis thaliana. Gutiérrez-Alanís et al. show that in response to low Pi, CLE14 peptide is expressed in proximal meristem, is perceived by CLV2 and PEPR2 receptors, and causes differentiation of surrounding RAM, leading to root meristem exhaustion.


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