Sr/ZnO doped titania nanotube array: An effective surface system with excellent osteoinductivity and self-antibacterial activity

Publication date: 15 September 2017
Source:Materials & Design, Volume 130
Author(s): Kejia Zhang, Yizhou Zhu, Xiangmei Liu, Zhenduo Cui, XianjinYang, Kelvin W.K. Yeung, Haobo Pan, Shuilin Wu
Both excellent osteoinductivity and self-antibacterial performance are important for the successful clinical application of Ti-based metals as bone implant materials. Titania nanotube (TNT) arrays can endow Ti-based materials with multi-biofunctions due to the unique geometric structures of TNT that can be directly functionalized on the substrates through diverse techniques. In this work, strontium (Sr) and zinc oxides (ZnO) were doped into TNT arrays successively by hydrothermal treatment (HT) and subsequent atomic layer deposition (ALD). The super hydrophobic TNT array was obtained by grafting octadecylphosphonic acid (OPDA)-toluene. The results showed that the dual doping of Sr and ZnO together with super-hydrophobic property could not only enhance the osteoinductivity of Ti-based implants but also endow these implant materials with effective self-antibacterial ability. The former was ascribed to the osteogenic effects of Sr while the latter was contributed to the synergistic effects of ZnO and hydrophobic of OPDA.

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