TREX1 Cuts Down on Cancer Immunogenicity

Publication date: Available online 15 June 2017
Source:Trends in Cell Biology
Author(s): Takahiro Yamazaki, Lorenzo Galluzzi
Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT).



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