Dynamic nuclear polarization for sensitivity enhancement in modern solid-state NMR

Publication date: Available online 23 July 2017
Source:Progress in Nuclear Magnetic Resonance Spectroscopy
Author(s): Aany Sofia Lilly Thankamony, Johannes J. Wittmann, Monu Kaushik, Björn Corzilius
The field of dynamic nuclear polarization has undergone tremendous developments and diversification since its inception more than 6 decades ago. In this review we will provide an in-depth overview of the relevant topics involved in DNP-enhanced MAS NMR spectroscopy. This includes the theoretical description of DNP mechanisms as well as of the polarization transfer pathways that can lead to a uniform or selective spreading of polarization between nuclear spins. Furthermore, we will cover historical and state-of-the art aspects of dedicated instrumentation, polarizing agents, and optimization techniques for efficient MAS DNP. Finally, we present an extensive overview on applications in the fields of structural biology and materials science, that underlines that MAS DNP has moved far beyond the proof-of-concept stage and has become an important tool for research in these fields.Edited by Geoffrey Bodenhausen and Beat Meier

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