Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

Publication date: 5 July 2017
Source:Cell Metabolism, Volume 26, Issue 1
Author(s): Frances M. Ashcroft, Maria Rohm, Anne Clark, Melissa F. Brereton
Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in β cells in normoglycemia and in diabetes.

Teaser

The presence of glycogen in the pancreatic β cell, its implications for the regulation of β cell metabolism, and its role in β cell dysfunction have recently gained increasing attention. Here, Ashcroft et al. review emerging data and re-examine past findings on the role of glycogen in β cells in both normoglycemia and diabetes.


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