For Embryos, Mother Can Only Take You So Far

Publication date: 7 August 2017
Source:Developmental Cell, Volume 42, Issue 3
Author(s): Patrick L. Ferree, Stefano Di Talia
Early embryonic development is characterized by rapid cleavage divisions, which impose significant constraints on metabolic pathways. In this issue, Song et al. (2017) show that Drosophila embryos synthesize a large fraction of nucleotides on the go and that negative feedback between dATP and ribonucleotide reductase ensures tight control of dNTP concentration.

Teaser

Early embryonic development is characterized by rapid cleavage divisions, which impose significant constraints on metabolic pathways. In this issue, Song et al. (2017) show that Drosophila embryos synthesize a large fraction of nucleotides on the go and that negative feedback between dATP and ribonucleotide reductase ensures tight control of dNTP concentration.


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