Optic Disc Drusen in Children: The Copenhagen Child Cohort 2000 Eye Study.

Background: Optic disc drusen (ODD) are seen in up to 2.4% of the general population, but the etiology and pathophysiology of the condition is still unknown. The purpose of this study was to determine the prevalence of ODD in a population-based child cohort and to determine if scleral canal diameter and fetal birth and pubertal parameters are associated with the presence of ODD. Methods: This observational, longitudinal population-based birth cohort study, with a nested case-control, included 1,406 children. Eye examinations were performed when the children were between 11 and 12 years of age. Assessment was performed of optical coherence tomography (OCT) scans from 1,304 children with gradable enhanced depth imaging scans of the optic disc. Results: ODD in one or both eyes were found in 13 (1.0%) of all children. All but one of the cases were found in children with scleral canal diameter in the lowest quartile (1,182-1,399 [mu]m) in the nested case-control study. Children with ODD had a mean disc diameter of 1,339 [mu]m (interquartile range, 30 [mu]m), whereas it was 1,508 [mu]m (interquartile range, 196 [mu]m) in the 130 controls without ODD (P

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