The Molecular Basis of Erythrocyte Invasion by Malaria Parasites

Publication date: 9 August 2017
Source:Cell Host & Microbe, Volume 22, Issue 2
Author(s): Alan F. Cowman, Christopher J. Tonkin, Wai-Hong Tham, Manoj T. Duraisingh
Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of immunologically privileged erythrocytes provides a relatively protective niche as well as access to a rich source of nutrients. Plasmodium spp. target erythrocytes of different ages, but share a common mechanism of invasion. Specific engagement of erythrocyte receptors defines target cell tropism, activating downstream events and resulting in the physical penetration of the erythrocyte, powered by the parasite's actinomyosin-based motor. Here we review the latest in our understanding of the molecular composition of this highly complex and fascinating biological process.

Teaser

Malaria parasites invade erythrocytes, a host cell that provides a protective niche and rich source of nutrients. In this review, Cowman et al. examine this invasion process and the roles of multiple ligand-receptor interactions that define target cell tropism, and activate downstream events resulting in physical penetration of the erythrocyte.


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