Host Genetic Control of the Oral Microbiome in Health and Disease

Publication date: 13 September 2017
Source:Cell Host & Microbe, Volume 22, Issue 3
Author(s): Andres Gomez, Josh L. Espinoza, Derek M. Harkins, Pamela Leong, Richard Saffery, Michelle Bockmann, Manolito Torralba, Claire Kuelbs, Rohith Kodukula, Jason Inman, Toby Hughes, Jeffrey M. Craig, Sarah K. Highlander, Marcus B. Jones, Chris L. Dupont, Karen E. Nelson
Host-associated microbial communities are influenced by both host genetics and environmental factors. However, factors controlling the human oral microbiome and their impact on disease remain to be investigated. To determine the combined and relative effects of host genotype and environment on oral microbiome composition and caries phenotypes, we profiled the supragingival plaque microbiome of 485 dizygotic and monozygotic twins aged 5–11. Oral microbiome similarity always increased with shared host genotype, regardless of caries state. Additionally, although most of the variation in the oral microbiome was determined by environmental factors, highly heritable oral taxa were identified. The most heritable oral bacteria were not associated with caries state, did not tend to co-occur with other taxa, and decreased in abundance with age and sugar consumption frequency. Thus, while the human oral microbiome composition is influenced by host genetic background, potentially cariogenic taxa are likely not controlled by genetic factors.

Graphical abstract

Teaser

Gomez et al. examine the supragingival plaque microbiome of 5- to 11-year-old twins and find that the early oral microbiome is shaped by both heritable and environmental factors. However, the most heritable bacteria diminish in abundance with age, and potentially cariogenic taxa are not controlled by host genetics.


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