Publication date: Available online 23 September 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Jéssica Venância Faria, Percilene Fazolin Vegi, Ana Gabriella Carvalho Miguita, Maurício Silva dos Santos, Nubia Boechat, Alice Maria Rolim Bernardino
The pyrazole nucleus is an aromatic azole heterocycle with two adjacent nitrogen atoms. Pyrazole derivatives have exhibited a broad spectrum of biological activities, and approved pyrazole-containing drugs include celecoxib, antipyrine, phenylbutazone, rimonabant, and dipirone. Many research groups have synthesized and evaluated pyrazoles against several biological agents. This review examines recent publications relating the structures of pyrazoles with their corresponding biological activities.
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