18F-FDG PET/contrast enhanced CT in the standard follow-up of patients with lymphoma

Publication date: Available online 27 October 2017
Source:Revista Española de Medicina Nuclear e Imagen Molecular
Author(s): A.M. García Vicente, M.P. Talavera Rubio, E. Dominguez Ferreras, C. Calle Primo, M. Amo-Salas, M.J. Tello Galán, G.A. Jiménez Londoño, F. Jiménez Aragón, B. Hernández Ruiz, Á. Soriano Castrejón
AimTo assess the diagnostic accuracy of ¹⁸F-FDG PET/contrast enhanced computed tomography (ceCT) in the detection of asymptomatic recurrences in patients with lymphoma.Material and methodsPatients with lymphoma and clinical complete remission underwent ¹⁸F-FDG PET/ceCT for standard follow-up.¹⁸F-FDG PET and ceCT were evaluated blindly by two independent observers, and classified as positive or negative for recurrence. Additionally a combined evaluation of both techniques was performed.The final diagnosis was established by histopathological analysis or a clinical follow-up longer than 6 months.Statistical diagnostic parameters and concordance levels between both diagnostic techniques were calculated.ResultsA total of 114 explorations on 90 patients were analyzed. Only 4 patients were diagnosed as asymptomatic recurrence during the follow-up.¹⁸F-FDG PET/ceCT, ¹⁸F-FDG PET and ceCT showed an association with the final diagnosis (p=.002 and χ²=11.96; p<.001 and χ²=15.60; p=.001 and χ²=11.96, respectively). The concordance between ¹⁸F-FDG PET and ceCT was moderate/high and significant (Kappa=0.672; p<.001).A sensitivity and specificity of 50% and 88% was obtained for the ¹⁸F-FDG PET/ceCT civ, 50% and 93% for the ¹⁸F-FDG PET, and 50% and 91% for the ceCT.ConclusionThe combined use of ¹⁸F-FDG PET/ceCT did not offer any advantage compared to any isolated diagnostic technique in the detection of asymptomatic lymphoma recurrence.



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