Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR

Publication date: 9 October 2017
Source:Developmental Cell, Volume 43, Issue 1
Author(s): Ben Ewen-Campen, Stephanie E. Mohr, Yanhui Hu, Norbert Perrimon
Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype gap" and impact biomedical research.

Teaser

Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype gap" and impact biomedical research.


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