Ετικέτες

Τρίτη 10 Οκτωβρίου 2017

Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy

Publication date: 9 October 2017
Source:Cancer Cell, Volume 32, Issue 4
Author(s): W. Nathaniel Brennen, John T. Isaacs
In this issue of Cancer Cell, Bluemn et al. report that ∼20% of metastatic castration-resistant prostate cancers express neither AR nor neuroendocrine genes and show AR pathway-independent growth, driven instead by a FGFR/MAPK/ID1 signaling cascade. These results provide a strong rationale for co-targeting AR bypass pathways with initial AR antagonism.

Teaser

In this issue of Cancer Cell, Bluemn et al. report that ∼20% of metastatic castration-resistant prostate cancers express neither AR nor neuroendocrine genes and show AR pathway-independent growth, driven instead by a FGFR/MAPK/ID1 signaling cascade. These results provide a strong rationale for co-targeting AR bypass pathways with initial AR antagonism.


http://ift.tt/2gpKhJF

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Αναζήτηση αυτού του ιστολογίου