Source:Clinical Neurophysiology
Author(s): Lihua Gu, Jiu Chen, Lijuan Gao, Hao Shu, Zan Wang, Duan Liu, Yanna Yan, Shijiang Li, Zhijun Zhang
ObjectivesThe study aimed to investigate and compare the effect of cognitive reserve (CR) on brain activation in healthy controls (HC) and amnestic mild cognitive impairment (aMCI) patients during 0-back and 1-back tasks measured by event-related potential (ERP).MethodsThe study recorded 85 subjects (39 aMCI patients and 46 their matched controls) with a 64-channel electroencephalogram (EEG). Subjects performed 0- and 1-back tasks.ResultsCompared to HC, aMCI patients showed reduced accuracy, delayed mean correct response time (RT) and decreased P300 amplitude at central-parietal and parietal electrodes. A mediation analysis indicated that higher CR reduced neural inefficiency, which might be associated with better task performance in HC. However, no correlation was detected between CR and neural inefficiency in aMCI patients, whereas higher CR was still related to enhanced accuracy and prolonged RT in aMCI patients.ConclusionsThe present study reported that higher CR could contribute to better task performance via down-regulating neural inefficiency in HC. In addition, higher CR might modulate attention processes in aMCI via a way distinct from that in HC, and eventually result in better task performance.SignificanceThe study provided evidence for that improving CR might lower cognitive impairment of healthy elderly and aMCI patients.
http://ift.tt/2iLoM6k
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