Protein overexpression and gene amplification of cellular mesenchymal-epithelial transition factor is associated with poor prognosis in micropapillary predominant subtype pulmonary adenocarcinoma

Publication date: Available online 9 November 2017
Source:Human Pathology
Author(s): Jing Zhang, Jian Sun, Zhiwen Zhang, Xiaolong Liang, Yufeng Luo, Shafei Wu, Zhiyong Liang
Micropapillary predominant subtype pulmonary adenocarcinoma (MPPAC) is a subtype of lung cancer with poor prognosis. Cellular mesenchymal-epithelial transition factor (c-MET) is a promising pharmaceutic target found to be associated with the survival of patients with pulmonary adenocarcinoma (PAC). In this study, we aimed to analyze c-MET protein overexpression and gene amplification in MPPAC samples and to elucidate their relationship with the clinicopathological characteristics of the patients. c-MET protein expression was examined by immunohistochemical analyses, and gene amplification was detected by fluorescence in situ hybridization(FISH). A total of 86 MPPAC cases were included in this study. The prevalence of c-MET protein overexpression and gene amplification were 62.8% and 10.5%, respectively. C-MET protein overexpression was significantly associated with smoking status, lymphatic and venous invasion and Tumor Node Metastasis(TNM) stage (P=.014, P=.040, and P=.004, respectively), but c-MET gene amplification showed no relation with any of these characteristics. Univariate analysis revealed that pleural invasion, lymph node metastasis, lymphatic and venous invasion, TNM stage, c-MET protein overexpression, and c-MET gene amplification were associated with poor prognosis (P=.041, P<.001, P=.001, P<.001, P=.001 and P=.001, respectively), but only c-MET gene amplification was an independent prognostic marker (P=.04). These results indicated that c-MET is an important biomarker. Also c-MET protein overexpression and gene amplification are highly related to poor prognosis in patients with MPPAC.



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