Summary
Background
Cholecalciferol and/or calcium supplementation might increase skeletal-muscle strength and serum testosterone in young adult males.
Objective: We performed a randomized-control-trial assessing the effect of cholecalciferol/calcium on skeletal-muscle strength and serum testosterone in vitamin-D deficient young males.
Design
Two-by-two factorial RCT.
Subject and Intervention
Two-hundred and twenty-eight young males were block-randomized to 1) double-placebo, 2) calcium/placebo, 3) cholecalciferol/placebo, and 4) cholecalciferol/calcium. Doses for cholecalciferol was 60,000 IU/wk for eight-weeks followed by 60,000 IU/fortnightly and for elemental calcium was 500 mg/twice daily for six-months. 180 subjects completed the study protocol. Their mean age, body-mass-index, and baseline 25(OH)D were 20.2 ± 2.2 years, 23.0 ± 3.6 kg/m2, and 21.5 ± 9.5 nmol/l, respectively.
Measurements
Handgrip (primary outcome), pinch-grip strength, distance walked in six-minutes, dyspnoea-score, quality of life by Short-Form-36, serum 25(OH)D, 1,25(OH)2D, iPTH, total testosterone and free-androgen-index (FAI).
Results
After intervention, mean serum 25(OH)D was > 75.0 nmol/l in cholecalciferol groups. However, the handgrip strength (29.7 ± 4.4, 29.3 ± 4.6, 30.6 ± 5.0, and 28.8 ± 4.3 kg, P = 0.28) were comparable in the four groups. Subgroups analysis among subjects with baseline serum 25OH)D < 25.0 and < 12.0 nmol/l showed similar results. The mean serum testosterone decreased significantly at six-months; however, delta change was similar in four groups. Change in handgrip strength and other outcomes were similar in four groups with and without adjustment for delta testosterone and FAI.
Conclusions
Six-months of cholecalciferol/calcium supplementation had no significant effect on skeletal-muscle strength and serum testosterone in young adult males.
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