Redox Clocks: Time to Rethink Redox Interventions

Publication date: Available online 26 December 2017
Source:Free Radical Biology and Medicine
Author(s): Andras D. Nagy, Akhilesh B. Reddy
Redox interventions have been controversial in the management of chronic disease. The key reason is believed to be a lack of clarity in our understanding of how endogenous dynamics unfold in biochemical redox mechanisms in live cells. Time-resolved, quantitative research strategies combined with high throughput analysis tools may result in realistic characterisation of related in vivo processes. Here we review new evidence about redox dynamics in live cells. We discuss a potential of this line of research to establish new and affordable ways of redox interventions which may efficiently decrease mortality related to largely preventable chronic diseases.

Graphical abstract

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