5-Fluorouracil 0.5% and Salicylic Acid 10.0% (Actikerall) [Internet].

According to the British Association of Dermatologists, 15% to 25% of actinic keratosis (AK) lesions spontaneously resolve during a one-year period. However, AK lesions may develop into invasive squamous cell carcinoma (SCC) if left untreated. The rate of progression from AK to SCC is unknown. Mathematical models derived from a study predicted that for an individual with an average of 7.7 AKs, the probability of developing an SCC at the same or nearby site within a 10-year period is approximately 10. The risk of malignant transformation is higher in patients who are immunocompromised. In Canada, 74,100 new cases of non-melanoma skin cancers (NMSCs) and 270 deaths due to these cancers were predicted for 2011.

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