Genomic stability and telomere regulation in skeletal muscle tissue

Publication date: February 2018
Source:Biomedicine & Pharmacotherapy, Volume 98
Author(s): Larissa Alexsandra da Silva Neto Trajano, Eduardo Tavares Lima Trajano, Marco Aurélio dos Santos Silva, Ana Carolina Stumbo, Andre Luiz Mencalha, Adenilson de Souza da Fonseca
Muscle injuries are common, especially in sports and cumulative trauma disorder, and their repair is influenced by free radical formation, which causes damages in lipids, proteins and DNA. Oxidative DNA damages are repaired by base excision repair and nucleotide excision repair, ensuring telomeric and genomic stability. There are few studies on this topic in skeletal muscle cells. This review focuses on base excision repair and nucleotide excision repair, telomere regulation and how telomeric stabilization influences healthy muscle, injured muscle, exercise, and its relationship with aging. In skeletal muscle, genomic stabilization and telomere regulation seem to play an important role in tissue health, influencing muscle injury repair. Thus, therapies targeting mechanisms of DNA repair and telomeric regulation could be new approaches for improving repair and prevention of skeletal muscle injuries in young and old people.



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