20S proteasome in the blood plasma of boys with cryptorchidism

Abstract

Purpose

To evaluate the concentration of 20S proteasome in the blood plasma of boys with cryptorchidism.

Methods

Patients—50 boys aged 1–4 years (median = 2.4 years) with unilateral cryptorchidism. The control group—50 healthy, age-matched boys (aged 1–4 years, median = 2.1 years), admitted for planned herniotomy. In our study, we used a novel technique Surface PLASMON RESONANCE Imaging.

Results

The median concentration of 20S proteasome in the blood plasma of boys with cryptorchidism was 2.5-fold higher than in boys with inguinal hernia. We noticed statistically significant difference between 20S proteasome levels in boys with cryptorchidism up to 2 years old and above 2 years old.

Conclusions

We believe that the 20S proteasome concentrations in the blood plasma of boys with cryptorchidism reflect the heat-induced apoptosis of germ cells.

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