Active principles of Tetradenia riparia. IV. Anthelmintic activity of 8(14),15-sandaracopimaradiene-7α,18-diol

Publication date: 24 April 2018
Source:Journal of Ethnopharmacology, Volume 216
Author(s): Luc Van Puyvelde, Maoxuan Liu, Cedrick Veryser, Wim M. De Borggraeve, Joseph Mungarulire, Marie Jeanne Mukazayire, Walter Luyten
Ethnopharmacological relevanceTetradenia (T.) riparia (Hochst.) Codd (Lamiaceae), formerly known as Iboza riparia (Hochst.) N.E.Br., is one of the most frequently used medicinal plants in traditional Rwandese medicine. It was used as a remedy against a wide range of diseases including malaria, angina, yaws, dental abscesses, headache, worm infections and several kinds of fevers and aches.Aim of the studyThis study aims to identify the compounds active against helminths from Tetradenia riparia.MethodsA bioassay-guided isolation of anthelmintic compounds from the leaves of Tetradenia riparia was performed using a Caenorhabditis elegans (C. elegans) testing model.ResultsThe bioassay-guided isolation led to one active compound, i.e. 8(14),15-sandaracopimaradiene-7α,18-diol. Its IC50 value was 5.4 ± 0.9 µg/mL (17.8 ± 2.9 µM).ConclusionsWe identified the bioactive compound from Tetradenia riparia responsible for its anthelmintic activity: 8(14),15-sandaracopimaradiene-7α,18-diol. Although the compound and several of its bioactivities have been described before, this is the first report of its anthelmintic effect.



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