An Intrinsic Interferon Program Protects Stem Cells from Viral Infection

Publication date: 5 February 2018
Source:Developmental Cell, Volume 44, Issue 3
Author(s): Simon Haas, Andreas Trumpp
Specific protection mechanisms are required to safeguard stem cell integrity. In a recent issue of Cell, Wu et al. (2018) show that stem cells are equipped with high intrinsic expression of interferon-stimulated genes (ISGs) but remain refractory to acute interferon signaling. This protects stem cells from viral infection.

Teaser

Specific protection mechanisms are required to safeguard stem cell integrity. In a recent issue of Cell, Wu et al. (2018) show that stem cells are equipped with high intrinsic expression of interferon-stimulated genes (ISGs) but remain refractory to acute interferon signaling. This protects stem cells from viral infection.


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