Association between epicardial fat volume and fractional flow reserve: An analysis of the determination of fractional flow reserve (DeFACTO) study

Publication date: September–October 2018
Source:Clinical Imaging, Volume 51
Author(s): Ashley Beecy, Bríain Ó. Hartaigh, Joshua Schulman-Marcus, Khalil Anchouche, Heidi Gransar, Subhi Al'Aref, Kimberly Elmore, Fay Y. Lin, James K. Min, Jessica M. Peña
BackgroundThis study examines the relationship between epicardial fat volume (EFV) and lesion-specific ischemia by fractional flow reserve (FFR).MethodsIn a study of 173 patients (63.0 ± 8.3 years) undergoing FFR, EFV was determined using cardiac computed tomography. Relationships between EFV and FFR were assessed using multivariable linear and logistic regression.ResultsUsing multivariable linear and logistic regression, no association between EFV and FFR was observed (β [SE] = −0.001 [0.003], P = 0.6, OR [95% CI]: 1.02 [0.94–1.11], P = 0.64, respectively).ConclusionIn patients with suspected or known coronary artery disease undergoing invasive angiography, EFV was not associated with FFR.



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