ATP Citrate Lyase: A New Player Linking Skeletal Muscle Metabolism and Epigenetics

Publication date: Available online 31 January 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Haisen Li, Vittorio Sartorelli
Intermediates generated in several metabolic processes are used to regulate transcription through covalent histone and DNA modifications. In Cell Reports, Das et al. show that acetyl-coenzyme A (acetyl-CoA) generated by ATP citrate lyase (ACL) is utilized to acetylate histone H3 at MyoD regulatory regions, resulting in increased MyoD expression and improved muscle regeneration after injury.



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