Metabolite-Induced Protein Expression Guided by Metabolomics and Systems Biology

Publication date: 6 February 2018
Source:Cell Metabolism, Volume 27, Issue 2
Author(s): Martin Giera, Filipe Branco dos Santos, Gary Siuzdak
Metabolomics combined with systems biology can be used to identify endogenous metabolites that modulate protein expression. Recent examples include the 2-fold enhancements of pertussis toxin protein in vaccine production and myelin basic protein expression in oligodendrocyte maturation; both applied a metabolomics-systems strategy to identify active metabolites.

Teaser

Metabolomics combined with systems biology can be used to identify endogenous metabolites that modulate protein expression. Recent examples include the 2-fold enhancements of pertussis toxin protein in vaccine production and myelin basic protein expression in oligodendrocyte maturation; both applied a metabolomics-systems strategy to identify active metabolites.


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