Regulation of epithelial to mesenchymal transition by BRCA1 in breast cancer

Publication date: March 2018
Source:Critical Reviews in Oncology/Hematology, Volume 123
Author(s): Satheesh Kumar Sengodan, Sreelatha K.H., Revathy Nadhan, Priya Srinivas
Reports till its discovery has proven multiple facets of Breast Cancer type 1 susceptibility gene (BRCA1) from nucleus to cytoplasm; from DNA repair to drug resistance; from Homologous Recombination (HR) to Ubiquitination; from breast to brain; from cancer to HIV and many of the roles are still unexplored. One of the recent attractions of BRCA1 is its role in regulating breast cancer metastasis though the exact mechanism is poorly understood. In this review, we will discuss the molecular interactions between BRCA1 and the key molecules of Epithelial to Mesenchymal Transition (EMT) associated with metastasis, its associated drug resistance and the possible treatment strategy for BRCA1 mutated breast cancer.



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