Taking Aim at Glycolysis with CDK8 Inhibitors

Publication date: Available online 20 February 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Robert P. Fisher
Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.



http://ift.tt/2BEXhXi