Publication date: June 2018
Source:Data in Brief, Volume 18
Author(s): Gillian Warner-Søderholm, Andy Bertsch, Annika Søderholm
This article contains data collected from self-report surveys of respondents to measure 1) social media usage, 2) age, 3) gender and 4) trust, measured within five major trust constructs of a) Integrity, b) Competence, c) Concern, d) Benevolence and e) Identification. The data includes all instruments used, SPSS syntax, the raw survey data and descriptive statistics from the analyses. Raw data was entered into SPSS software and scrubbed using appropriate techniques in order to prepare the data for analysis. We believe that our dataset and instrument may give important insights related to computers in human behavior, and predicting trust antecedents in social media use such as age, gender, number of hour online and choice of content provider. We have also created a parsimonious five factor trust instrument developed from the extant literature for future research. Hence, this newly developed trust instrument can be used to measure trust not only in social media, but also in other areas such as healthcare, economics and investor relations, CSR, management and education. Moreover, the survey items developed to measure social media use are concise and may be applied to measure social media use in other contexts such as national cultural differences, marketing and tourism. For interpretation and discussion of the data and constructs, please see original article entitled "Who trusts social media" (Warner-Søderholm et al., 2018) [1].
https://ift.tt/2Jap1EG
Σάββατο 31 Μαρτίου 2018
Data on social media use related to age, gender and trust constructs of integrity, competence, concern, benevolence and identification
Transcription profile data of phorbol esters biosynthetic genes during developmental stages in Jatropha curcas
Source:Data in Brief, Volume 18
Author(s): Nurul Jadid, Rizal Kharisma Mardika, Kristanti Indah Purwani, Erlyta Vivi Permatasari, Indah Prasetyowati, Mohammad Isa Irawan
Jatropha curcas is currently known as an alternative source for biodiesel production. Beside its high free fatty acid content, J. curcas also contains typical diterpenoid-toxic compounds of Euphorbiaceae plant namely phorbol esters. This article present the transcription profile data of genes involved in the biosynthesis of phorbol esters at different developmental stages of leaves, fruit, and seed in Jatropha curcas. Transcriptional profiles were analyzed using reverse transcription-polymerase chain reaction (RT-PCR). We used two genes including GGPPS (Geranylgeranyl diphospate synthase), which is responsible for the formation of common diterpenoid precursor (GGPP) and CS (Casbene Synthase), which functions in the synthesis of casbene. Meanwhile, J. curcas Actin (ACT) was used as internal standard. We demonstrated dynamic of GGPPS and CS expression among different stage of development of leaves, fruit and seed in Jatropha.
https://ift.tt/2EaSMRO
Key gene co-expression modules and functional pathways involved in the pathogenesis of Graves’ disease
Source:Molecular and Cellular Endocrinology
Author(s): Xiaoqing Shao, Bin Wang, Kaida Mu, Ling Li, Qian Li, Weiwei He, Qiuming Yao, Xi Jia, Jin-an Zhang
Graves' disease (GD) is a common autoimmune thyroid disease characterized by positive thyroid stimulating hormone receptor antibody. To better understand its molecular pathogenesis, we adopted the weighted gene co-expression network analysis to reveal co-expression modules of key genes involved in the pathogenesis of GD, protein-protein interaction network analysis to identify the hub genes related to GD development and functional analyses to explore their possible functions. Our results showed that 1) a total of 2667 differentially expressed genes in our microarray study and 16 different gene co-expression modules were associated with GD, and 2) the most significant module was associated with the percentage of macrophages, T follicular helper cells and CD4+ memory T cells and mainly enriched in immune regulation and immune response. Overall, our study reveals several key gene co-expression modules and functional pathways involved in GD, which provides some novel insights into the pathogenesis of GD.
https://ift.tt/2Eb9Kzs
Maternal lipopolysaccharide exposure results in glucose metabolism disorders and sex hormone imbalance in male offspring
Publication date: Available online 1 April 2018
Source:Molecular and Cellular Endocrinology
Author(s): Mei Zhao, Li Yuan, Man-man Yuan, Li-li Huang, Chang Su, Yuan-hua Chen, Yu-ying Yang, Yan Hu, De-xiang Xu
An adverse intrauterine environment may be an important factor contributing to the development of type 2 diabetes in later life. The present study investigated the longitudinal effects of maternal lipopolysaccharide (LPS) exposure during the third trimester on glucose metabolism and sex hormone balance in the offspring. Pregnant mice were intraperitoneally injected with LPS (50 μg/kg) daily from gestational day (GD) 15 to GD17. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were assessed at postnatal day (PND) 60 and PND120. Sex hormones, their receptors, and metabolic enzymes (aromatase) were measured in male offspring at different phases of development (PND14: juvenile; PND35: adolescence; PND60: adulthood; and PND120: middle age). LPS-exposed male offspring exhibited glucose intolerance and insulin resistance by GTT and ITT at middle age, accompanied by an increase in fasting blood glucose and reductions in serum insulin levels and hepatic phosphorylated (p) -AKT/AKT ratio. However, glucose intolerance and insulin resistance were not observed in LPS-exposed female offspring. Maternal LPS exposure upregulated hepatic aromatase proteins and mRNA levels in male offspring at all time points. At adolescence, the testosterone/estradiol ratio (T/E2) was markedly reduced in LPS-exposed male offspring. Moreover, maternal LPS exposure significantly increased hepatic estrogen receptor (ER) α expressions and decreased hepatic androgen receptor (AR) expressions in male offspring. At adulthood, maternal LPS exposure increased serum estradiol levels, decreased serum testosterone levels and elevated hepatic ERβ expressions in male offspring. In conclusion, maternal LPS exposure upregulated aromatase expressions, followed by a reduction in the T/E2 ratio and an alteration in sex hormone receptor activity, which might be involved in the development of glucose metabolism disorders in middle-aged male offspring. This study provides a novel clue and direction to clarify the pathogenesis of maternal infection-related diabetes in male offspring.
https://ift.tt/2H0mEn9
Scholar : Chinese Archives of Otolaryngology-Head and Neck Surgery, Year 2018, Issue 01 -New Issue Alert.
Scholar : International Journal of Ophthalmology, Year 2018, Issue 03 -New Issue Alert.
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Scholar : Chinese Journal of Otorhinolaryngology-skull Base Surgery, Year 2018, Issue 01 -New Issue Alert.
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Scholar : Journal of Clinical Stomatology, Year 2018, Issue 02 -New Issue Alert.
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