The Endothelial–Metabolic Axis: A Novel Cardiometabolic Disease Target

Publication date: Available online 31 March 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Jason C. Kovacic
Endothelial to mesenchymal transition (EndMT) involves cellular phenotypic switching from an endothelial to mesenchymal state. Interest in EndMT has been increasing with the appreciation that it has an important role in several cardiovascular diseases. New evidence indicates that fatty acid oxidation (FAO) and cell metabolism are major factors controlling this process.



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