Publication date: April 2018
Source:Clinical Neurophysiology, Volume 129, Issue 4
Author(s): L. Brabenec, J. Mekyska, Z. Galáž, P. Klobušiakova, M. Koštálová, I. Rektorova
IntroductionHypokinetic dysarthria (HD) is a common symptom of Parkinson's disease (PD) which does not respond well to PD treatments. We investigated short-term effects of repetitive transcranial magnetic stimulation (rTMS) on HD in PD using acoustic analysis of speech.MethodsWe used both high and low frequency rTMS applied over the right posterior superior temporal gyrus (STG), the left orofacial primary motor area, and over the vertex (a control stimulation site) in 15 PD patients using a cross-over design. Resting state seed-based functional connectivity (rs-FC) with the seed located in the stimulation site was used to unravel the neural underpinnings of rTMS-induced behavioural changes.ResultsBoth 1 Hz and 10 Hz rTMS of the right STG induced some positive changes on HD. The major impact was observed for 1 Hz rTMS over the STG. The stimulation improved speech articulation and rhythmicity via modulation of the STG rs-FC with the parahippocampal gyrus and cerebellum. The 10 Hz rTMS of the STG improved articulation while enhancing the rs-FC with the inferior parietal lobule and thalamus.
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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