BAX and BAK at the Gates of Innate Immunity

Publication date: Available online 16 March 2018
Source:Trends in Cell Biology
Author(s): Lorenzo Galluzzi, Claire Vanpouille-Box
Large BAX/BAK pores that form during apoptosis enable mitochondrial nucleoids to access the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells to prevent inflammatory responses. BAX and BAK operate at the interface between apoptotic signaling and innate immunity control.



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