Source:Pediatric Neurology
Author(s): Qian Chen, Guixian Zhao, Yongheng Huang, Zhenxin Li, Xinghuai Sun, Ping Lu, Yan S, Min Wang, Guohong Tian
BackgroundThe clinical characteristics of pediatric optic neuritis (ON) patients with seropositive myelin oligodendrocyte glycoprotein (MOG) antibodies in Asian have not been reported.Main proceduresAcute onset ON patients ≤ 18-years-old were enrolled.Serum MOG and aquaporin-4 (AQP4) antibodies were detected and patients were followed-up for at least 6 months. The demographic, clinical and radiological features, together with optical coherence tomography (OCT) were evaluated among MOG-seropositive ON (MOG-ON), AQP4-seropositive ON (AQP4-ON) and double seronegative ON (seronegative-ON). Best corrected visual acuity (BCVA), thickness of optic disc retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) measured by OCT at 6 months after an acute attack. The clinical features in MOG seropositive pediatric ON were compared with other phenotypes.Main findingsAmong MOG-ON (n=10, eyes=19), AQP4-ON (n=9, eyes=15) and seronegative-ON (n=40, eyes=62), the percentages of BCVA measured better than 0.8 (20/25) at the 6-month visit were 89.47%, 33.33% and 82.26% respectively, which were significantly better in MOG-ON and seronegative-ON patients than that of AQP4-ON patients (p=0.02). The average peripapillary RNFL were 58.03±8.73µm, 64.34±12.88µm and 78.12±13.34µm for the MOG-ON, AQP4-ON and seronegative-ON patients respectively, which showed no statistic difference between MOG-ON and AQP4-ON patients (p=0.089), but were both thinner than seronegative-ON patients (p=0.001).ConclusionsThe recovery of visual acuity in MOG-ON patients was as good as in seronegative-ON patients, and the RNFL of the optic nerve head showed thinning as severe as the AQP4-ON patients.
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